Is SPINT1 a key regulator of placental development?

胎盘是胎盘物种生殖所必需的器官。本项目旨在阐明SPINT1在胎盘发育中的基础生物学。这将产生关于SPINT1的时空表达是否在几个物种中保持保守的新知识；牛、羊、蜥蜴、老鼠和人类。它还将定义SPINT1指导胎盘交换界面的形成、成熟和扩展的分子机制，胎盘交换界面对后代存活至关重要。 该项目将增加对胎盘发育的了解，加强合作和研究诀窍，并促进未来在所有通过胎盘支持繁殖的物种中的应用项目。

The placenta is an essential organ required for reproduction in placental species. This project aims to elucidate the fundamental biology of SPINT1 in placental development. It will generate new knowledge about whether the spatial and temporal expression of SPINT1 is conserved across several species; cow, sheep, lizard, mouse and human. It will also define the molecular mechanisms by which SPINT1 directs formation, maturation and expansion of the placental exchange interface which is critical for offspring survival. The project will increase understanding of placental development, enhance collaboration and research knowhow, and promote future applied projects in all species that reproduce via placental support.