Synthetic leukocytes: bio-inspired DNA nanorobots powered by flow

合成白细胞：由流动驱动的仿生 DNA 纳米机器人

• 批准号: DP220101528
• 负责人: Dr Shelley Wickham
• 金额: $ 41.66万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220101528
• 关键词: Synthetic; leukocytes; bio; inspired; DNA

Inspired by the way white blood cells roll along blood vessel walls, our goal is to build DNA nanorobots that roll along surfaces in flow. We take a synthetic biology approach to using biomolecules, such as DNA and proteins, to build functional particles and surfaces. To achieve this, we will combine our teams’ technological advances in DNA nanotechnology, plasma-activation for biomolecule immobilisation, and microfluidic devices. This project will contribute new methods for synthetic particle motion in flow and provide new insights into biomolecule interactions and motion. Ultimately, this will allow us to harness rolling for the delivery of synthetic nanorobots for detection and remediation in flow systems, such as the body.

受白细胞沿血管壁滚动方式的启发，我们的目标是建立在流动中沿表面滚动的DNA纳米机器人。我们采取了一种合成生物学的方法，使用生物分子，如DNA和蛋白质，来构建功能粒子和表面。为了实现这一目标，我们将结合我们团队在DNA纳米技术、用于生物分子固定化的等离子体激活和微流控设备方面的技术进步。该项目将为合成颗粒在流动中的运动提供新的方法，并为生物分子相互作用和运动提供新的见解。最终，这将使我们能够利用滚动来运送合成纳米机器人，以便在流动系统中进行检测和修复，例如身体。