Trearment for DIND and DND after subarachnoid hemorrhage

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We have detected c-fos and c-jun mRNA in cerebral cortex, hippocampus and dentate gyrus in the penetrated side after subarachnoid hemorrhage (SAH). mRNA coding for hsp7O was induced in the cerebral cortex, hippocampus, thalamus, hypothalamus, and caudoputamen in the penetrated side and extended to the contralateral side. In the TUNEL.method, only CAl neurons in the penetrated side showed apoptosis-like changes 48hr after SAH.The genes for bax and p53 were induced fairly in the CAl with peak between l2hr and 48hr which might cause apoptosis, although bcl-2 was also upregulated during the same period. The regulation of bax/bcl-2 ratio through p53 might influence apoptotic cell death. We investigated the effect of hypothermia on brain exposed to SAH.Mild hypothermia depressed hsp7O mRNA expression in the cortex, thalamus and hippocampus. The c-jun mRNA expression was also reduced with hypothermia in the cortex, thalamus and CA1. In the future, we indicated that hypothermia therapy might be one of the procedures to treat SAH.