Defining the antiviral effects of Wolbachia in Aedes aegypti mosquitoes

确定沃尔巴克氏体对埃及伊蚊的抗病毒作用

• 批准号: DP220102997
• 负责人: Dr Johanna Fraser
• 金额: $ 33.13万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-03-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220102997
• 关键词: Defining; antiviral; effects; Wolbachia; Aedes

Mosquitoes that carry a bacterium called Wolbachia do not transmit human pathogenic viruses. These mosquitoes are being developed as a biocontrol tool to prevent mosquito-borne diseases. This project aims to define the molecular basis for virus inhibition by Wolbachia. Using unique biological tools including mosquitoes carrying different strains of Wolbachia that do or do not inhibit dengue virus, the project will define how Wolbachia modifies its host to create an antiviral state. The findings will provide insight into how viral pathogens can be suppressed in insect hosts. This may guide future viral disease intervention strategies for diverse areas afflicted by insect-borne viral disease, including human health and agriculture.

携带一种名为沃尔巴克氏菌的细菌的蚊子不会传播人类致病病毒。这些蚊子正被开发为一种生物控制工具，以预防蚊媒疾病。本项目旨在确定沃尔巴克氏菌抑制病毒的分子基础。利用独特的生物工具，包括携带不同沃尔巴克氏菌株的蚊子，该项目将定义沃尔巴克氏菌如何修改宿主以创建抗病毒状态。这些发现将为病毒病原体如何在昆虫宿主中被抑制提供洞察力。这可能会指导未来对受昆虫传播的病毒疾病困扰的不同领域的病毒疾病干预战略，包括人类健康和农业。