Total Synthesis and Determination of Absolute Configuration of Carthamin ; A Red Pigment in the Petals of Safflower

红花花瓣的红色显色成分红花素的绝对构型为S， S。以红花素前体红花黄B、红花素A、红花素C和异红花素C为共同结构单元的其他黄色显色成分的绝对构型也同样确定为S， S。首次合成了含有链型葡萄糖的红花黄B模型化合物，其水解生成了少量的红花黄B模型化合物，以及红花黄B的生物合成途径。接下来，我们首先合成了Wasabidienone A，这是wasabidiae的代谢产物之一，具有高度氧化的结构，以及类似于红花素的酮-烯醇互变异构体的混合物。

Absolute configuration of Carthamin which is the red coloring component of safflower petals, was determined to be S, S.Furthermore, absolute configurations of the other yellow coloring components in which carthamin precursor, safflower yellow B, safflomin A, Safflomin C, and isosafflomin C bear C-glucosylquinochalcone as a common structural unit, were also determined to be S, S in the same way. Model compound of safflower yellow B which includes a chain-type glucose was first synthesized and its hydrolysis produced a small amount of carthamin-model compounds, as well as carthamin's biosynthetic pathway.Next, we first synthesized Wasabidienone A which is one of the metabolites of phoma wasabidiae, highly oxidized structure, and a mixture of keto-enol tautomers like carthamin.