Epigenetic regulation of immune memory

免疫记忆的表观遗传调控

• 批准号: DP220102867
• 负责人: Prof Kim Good-Jacobson
• 金额: $ 43.85万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-03-31 至 2025-03-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220102867
• 关键词: Epigenetic; regulation; immune; memory

Immune memory cells emerge from the dynamic and transient immune response to deliver two critical abilities: to produce rapid recall responses upon reinfection but also to persist for decades. This project aims to define how the polycomb repressive complexes regulate immune cell fate, by utilising cutting-edge cell and chromatin biology techniques coupled with bioinformatic pipelines. Expected outcomes of the proposed research include key insights into epigenetic programming required for immune cell differentiation and longevity. This should provide significant benefits such as knowledge creation that may lead to development of technology that reprograms cell behaviour, and contribution to Australian research recognition and capacity.

免疫记忆细胞从动态和短暂的免疫反应中产生，具有两种关键能力：在再次感染时产生快速回忆反应，而且能够持续数十年。该项目旨在通过利用尖端细胞和染色质生物学技术以及生物信息学流程来定义多梳抑制复合物如何调节免疫细胞命运。拟议研究的预期结果包括对免疫细胞分化和寿命所需的表观遗传编程的重要见解。这应该会带来显着的好处，例如知识创造，可能导致重新编程细胞行为的技术的发展，以及对澳大利亚研究认可和能力的贡献。