Circadian photoreceptor sensitivity and impacts of modern lighting on sleep

昼夜节律光感受器敏感性以及现代照明对睡眠的影响

• 批准号: DP220102812
• 负责人: A/Prof Andrew Phillips
• 金额: $ 30.8万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-03-15 至 2026-03-14
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220102812
• 关键词: Circadian; photoreceptor; sensitivity; impacts; modern

Light has powerful non-visual effects, including effects on sleep. These non-visual effects are mediated by cells in the eye that are most sensitive to blue light. There are large individual differences in sensitivity to non-visual effects of light that are not understood and that would give great insight into suboptimal sleep, which has become widespread in modern society. This study will be the first systematic examination of individual differences in the effect of blue light on sleep and will uncover how alterations in the gene responsible for the effects of blue light on sleep (OPN4) contribute to these differences. This will lead to scalable individualised solutions to the unmet problem of how modern light environments impact sleep.

光具有强大的非视觉效果，包括对睡眠的影响。这些非视觉效应由眼睛中对蓝光最敏感的细胞介导。对光线的非视觉效应的敏感性存在很大的个体差异，这些差异尚不清楚，这将使人们对现代社会中普遍存在的次优睡眠有更深入的了解。这项研究将是第一次系统地研究蓝光对睡眠影响的个体差异，并将揭示负责蓝光对睡眠影响的基因（OPN4）的改变如何导致这些差异。这将导致可扩展的个性化解决方案，以解决现代光环境如何影响睡眠的未解决问题。