Investigation of excitability and fatigue phenomenon in the corticospinal tract using transcortical magnetic stimulation.

使用经皮层磁刺激研究皮质脊髓束的兴奋性和疲劳现象。

• 批准号: 08670692
• 负责人: KUJIRAI Takashi
• 金额: $ 0.7万
• 依托单位: Yamagata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08670692/
• 关键词: cortical fatigue; magnetic stimulation; hand task; cortical modulation; Parkinson's disease; double magnetic stimulation technique; silent period; voluntary muscle contraction; 中枢性疲労; 大脳磁気刺激; 2重刺激法; サイレント ピアリド; 髄衰筋収縮; cortical fatigue; magne

(1) Experimental study in controlsBy using transcranial magnetic stimulation, fatigue phenomenon in the first dorsal interosseous muscle (FDI) was investigated in healthy volunteers during performance of two different manual tasks ; combination of flexion and abduction of index finger (FXA), and power grip (GP). Motor evoked responses (MEPs) were greatly suppressed in FXA task rather than in GP task. When conditionig digital nerve stimulation preceded the magnetic shocks, however, the decrement of MEP remained poor in ratio. In addition, peristimulus time histogram (PSTH) suggested that the suppression and maintenance of MEP in size were of cortical origin because of change of the number of motor unit counts (I-wave). The fatigue was also shown in other distal hand muscles, not in leg muscles.(2) Clinical studyIn order to verify whether corticospinal excitability was impaired in patients with Pakinson's disease, 10 patients and 10 age-matched controls were studied, after receiving info … More rmed consent. In the patient group, they were studied in two different days ; on the day they had ordinal L-DOPA therapy (ON-day) and on the day they were withdrawn from taking their medicine (OFF-day) at least over 12 hours. Motor evoked responses (MEPs) were recorded in the first dorsal interosseus muscle (FDI). Double magnetic stimulation technique (conditioning-test design) was applied. 10 trials for the test or conditioned shock were delivered, contralaterally to the target muscle at random. The intensity of the first conditionig shock was adjusted as 1.5 times of motor threshold of the target muscle at rest. The intensity of test shock was adjusted so that MEP at rest was around 1.0mV in the peak-to-peak amplitude. Conditioning-test intervals varied each 25 ms up to 125 ms. All applicants were studied in two situations ; at rest and and in activation. The conditioning shock induced silent period lasting up to around 150ms, following larger MEPs. At rest ; MEPs were greatly suppressed after 50 ms of CTI in both groups. In contrast, control subjects showed enhanced corticospinal excitability in activation between 25 and 125 ms of CTIs. Mean average of the excitability was 195%. In the patient group, it was 85% ON-DAY.Irrespective of L-DOPA therapy, the excitability in the patient group was greatly decreased, which suggests that the fatigue in patients with Parkinson's disease is probably in cortical origin. Less

(1)对照实验研究采用经颅磁刺激方法，观察了健康志愿者在食指屈曲外展(FXA)和力量握力(GP)两种不同体力动作时，第一骨间背肌(FDI)的疲劳现象。运动诱发反应(MEP)在FXA任务中受到明显抑制，而在GP任务中无明显抑制。然而，在磁刺激之前对指神经进行条件性刺激时，MEP的减少率仍然很低。此外，刺激前时间直方图(PSTH)提示MEP的抑制和维持源于皮质，这是由于运动单位计数(I波)的改变。为了验证帕金森病患者的皮质脊髓兴奋性是否受损，对10名帕金森病患者和10名年龄匹配的对照组在接受信息…治疗后进行了研究更愤怒的同意。在患者组中，他们在两个不同的天进行研究，在他们接受顺序的L-多巴治疗的当天(当天)和他们停药的当天(休息日)至少超过12小时。记录第一骨间背肌的运动诱发反应(MEP)。采用双磁刺激技术(条件性试验设计)。随机将10次试验或条件性休克的对侧提供给目标肌肉。首次条件性电击强度调整为静息时靶肌肉运动阈值的1.5倍。调整了测试冲击的强度，使静息状态下的MEP在峰间幅度约为1.0 mV。条件化-测试间隔每25ms变化一次，最高可达125ms。所有申请者都在两种情况下进行了研究：休息和活动。在较大的MEP之后，条件性休克诱导的静默期长达150ms左右。静息状态：CTI 50ms后，两组MEP均受到明显抑制。相反，对照组受试者在25到125ms的CTI激活时表现出更强的皮质脊髓兴奋性。兴奋性的平均值为195%。经L多巴治疗后，患者组兴奋性明显降低，提示帕金森病患者疲劳可能源于皮质。较少

项目成果

Takashi Kujirai, et al: "Reduced corticospinal excita oili by in the sirent perieod produced by muter kortical stimmiulation in pation tsunter parkinson′s diaease" Asion Oclanim Congress of Neurology. 9th. 53- (1996)

Takashi Kujirai 等人：“在帕金森氏病中，通过静音皮质刺激可减少皮质脊髓兴奋”，Asion Oclanim 神经学大会第 53 期（1996 年）。