Research on pathophysiology and prevention of neonatal ischemic brain damage using near infrared spectroscopy

近红外光谱研究新生儿缺血性脑损伤的病理生理学及预防

• 批准号: 08670928
• 负责人: YAMASHITA Yushiro
• 金额: $ 1.47万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08670928/
• 关键词: NIRS; indomethacin; hyperventilation; neonate; ischemia; prevention; exchange transfusion; Rett syndrome

We investigated the effect of indomethacin and hyperventilation on cerebral hemodynamics and oxygenation in newborn piglets using near infrared spectroscopy (NIRS). The piglets were divided into 2 groups. Indomethacin (Experimental group ; 0.2 mg/kg IV) or saline was administered after steady state, then each group was hyperventilated (pCO_2 ; 20 mm Hg). Cerebral oxyhemoglobin (Hb O_2) decreased immediately after indomethacin treatment compared to controls. This decrease continued for 15 minutes. During hyperventilation, Hb O_2 remained low compared to steady state in the experimental group. Total hemoglobin (Hb T) decreased simultaneously with Hb O_2. In the control group, no changes in Hb O_2 or Hb T were observed after saline administration, and only a slight decrease in Hb O_2 during the 5 minutes hyperventilation compared to steady state. No changes in cytochrome aa3 was observed in either group during 100% O_2 inhalation. We conclude that indomathacin decreased Hb O_2 and Hb T by vasoconstriction but that hyperventilation did not further aggravate this tendency. Great care should be taken when using indomethacin for newborn neonates. Using NIRS, we also investigated cerebral hemodynamics and oxygenation of neonates during exchange transfusion and of Rett patients with breathing abnormalities. NIRS provided useful information about cerebral hemodynamics and oxygenation in neonates and children. Monitoring specific patterns by NIRS may be useful for preventing brain damage.

采用近红外光谱技术研究了吲哚美辛和过度通气对新生仔猪脑血流动力学和氧合的影响。将仔猪分为2组。稳态后给予吲哚美辛（实验组; 0.2mg/kg IV）或生理盐水，然后各组过度通气（pCO_2 ; 20 mmHg）。脑氧合血红蛋白（Hb O_2）在吲哚美辛治疗后立即下降，与对照组相比。这种下降持续了15分钟。实验组过度通气期间Hb O_2仍低于稳态。总血红蛋白（Hb T）与Hb O_2同时下降。在对照组中，在给予生理盐水后，Hb O_2和Hb T没有观察到变化，在过度通气5 min期间，Hb O_2与稳态相比仅略有下降。吸入100%O_2时两组细胞色素aa 3均无明显变化。我们的结论是吲哚美辛通过血管收缩降低了Hb O_2和Hb T，但过度通气并没有进一步加重这种趋势。新生儿使用吲哚美辛时应特别小心。使用近红外光谱，我们还调查了脑血流动力学和氧合的新生儿在交换输血和Rett患者呼吸异常。NIRS提供了有关新生儿和儿童脑血流动力学和氧合的有用信息。通过NIRS监测特定模式可能有助于预防脑损伤。

项目成果

Murakami Y,Yamashita Y: "Changes of cerebral hemodynamics and oxygenation in unstable septic newborns during exchange transfusion." Kurume Medical Journal. 45. 321-325 (1998)

Murakami Y、Yamashita Y：“不稳定脓毒症新生儿换血期间脑血流动力学和氧合的变化。”

Murakami Y, Yamashita Y: "Cerebral oxygenation and hemodynamics during hyperventilation and sleep in patients with Rett syndrome" Brain and Development. 20. 574-578 (1998)

Murakami Y、Yamashita Y：“雷特综合征患者过度换气和睡眠期间的脑氧合和血流动力学”《大脑与发育》。

Murakami Y,Yamashita Y,Matsuishi T,Iwanaga R,Kato H: "Cerebral oxygenation and hemodynamics during hyperventilation and sleep in patients with Rett syndrome." Brain Dev. 20. 574-578 (1998)

Murakami Y、Yamashita Y、Matsuishi T、Iwanaga R、Kato H：“Rett 综合征患者过度换气和睡眠期间的脑氧合和血流动力学。”

Murakami Y, Yamashita Y: "Changes of cerebral hemodynamics ande oxygenation in unstable septic newborns during exchange transfusion." Kurume Medical Journal. 45. 321-325 (1998)

Murakami Y、Yamashita Y：“不稳定脓毒症新生儿换血期间脑血流动力学和氧合的变化。”

Murakami Y,Yamashita Y,Nishimi T,Inoue T,Matsuishi T,Kato H: "Changes of cerebral hemodynamics and oxygenation in unstable septic newborns during exchange transfusion." Kurume Med J. 45. 321-325 (1998)

Murakami Y、Yamashita Y、Nishimi T、Inoue T、Matsuishi T、Kato H：“不稳定脓毒症新生儿换血期间脑血流动力学和氧合的变化。”