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Study of the fluoride release restorative material on root caries of elderly patients

释氟修复材料对老年牙根龋的治疗研究

基本信息

批准号：
08672185
负责人：
KODAMA Linlin
金额：
$ 1.41万
依托单位：
Niigata University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1998
项目状态：
已结题

项目摘要

The purpose of this study, was to investigate the effect of a newly developed restorative material on the root caries of elderly patients or secondary caries. The newly developed restorative material has combined effect anti-canons & fluoride release properies. The study, first was to make the newly developed restorative material which composed of fluoride release glass ionomer cement & a mixture of anti-bacteria drug mainly metronidazole. The newly developed restorative material was tested for compressive strength, surface hardness, surface solubility, fluoride release, fluoride uptake for enamel and dentin, acid resistance of the tooth structures and it's anti-bacterial effect.The following results were obtained ;The sustained fluoride release from the newly developed restorative material was observed up more to 2 months period. The anti-bacterial sustained effect of newly developed restorative material, did not had big change on the material but was weaked, but sufficiently for restoration. Analysis material-enamel and dentin interface using an electron probe x-ray microanalyzer showed the fluoride uptake for enamel and dentin wall areas on contact parts with the fluoride releasing experimental materials. The test of acid resistance was by comparing the amount of dissolved calcium from enamel and dentin specimens in contact with experimental materials for 2 months ; it showed that there were smaller amount than those in contact with without-fluoride release materials sample(kept in deionized water or non-fluoride release materials). The acid resistance of fluoridated enamel and dentin specimens by experimental fluoride releasing materials was increased. From this study, it was confirmed that the newly developed restorative material is useful to root caries of elderly and it could prevent primary or sccondary caries.

本研究的目的是探讨一种新开发的修复材料对老年患者牙根龋或继发性龋的治疗效果。新开发的修复材料具有防加农炮和氟释放性能的综合效果。本研究首先研制了由氟释放玻璃离聚体水泥与以甲硝唑为主的抗菌药物混合组成的新型修复材料。对新研制的修复材料进行了抗压强度、表面硬度、表面溶解度、氟释放、牙釉质和牙本质对氟的吸收、牙齿结构的耐酸性和抗菌效果的测试。得到以下结果：从新开发的修复材料中观察到持续的氟化物释放长达2个月。新开发的修复材料的抗菌持续效果，对材料没有太大的变化，但较弱，但足以修复。使用电子探针x射线微量分析仪分析材料-牙釉质和牙本质界面，显示了氟释放实验材料接触部位牙釉质和牙本质壁面的氟吸收。耐酸试验通过对比牙本质和牙釉质试样与实验材料接触2个月后的溶钙量；结果表明，与无氟释放材料（去离子水或无氟释放材料）接触的样品相比，其残留量较小。实验释氟材料可提高氟化牙釉质和牙本质样品的耐酸性能。本研究证实了新开发的修复材料对老年人的龋病有根治作用，可以预防原发性或继发性龋病。