Study of the fluoride release restorative material on root caries of elderly patients

本研究的目的是探讨一种新开发的修复材料对老年人根面龋病或继发性龋病的治疗效果。新开发的修复材料具有综合效应、防正性和释氟性。本研究首先研制了一种新研制的含氟玻璃离子水门汀&以甲硝唑为主的抗菌药物混合物组成的修复材料。对新研制的修复材料进行了抗压强度、表面硬度、表面溶解性、氟化物释放、牙釉质和牙本质的吸氟量、牙齿结构的耐酸性和抗菌效果的测试，结果表明，新研制的修复材料的氟释放持续时间长达2个月以上。新研制的修复材料的抗菌效果持久，对材料没有太大的变化，但有所减弱，但足以修复。用电子探针X射线显微分析仪对材料-牙釉质-牙本质界面进行分析，结果表明与氟化物释放实验材料接触部位的牙釉质和牙本质壁区域摄氟量较大。耐酸试验通过比较牙釉质和牙本质标本与实验材料接触2个月后的溶出量，发现与无氟缓释材料接触的样品(保存在去离子水或非氟缓释材料中)相比，钙溶出量较少。实验用释氟材料可提高含氟牙釉质和牙本质试件的耐酸性。本研究证实，新研制的修复材料对老年人根面龋病有一定的治疗作用，并能预防原发或继发性龋病。

The purpose of this study, was to investigate the effect of a newly developed restorative material on the root caries of elderly patients or secondary caries. The newly developed restorative material has combined effect anti-canons & fluoride release properies. The study, first was to make the newly developed restorative material which composed of fluoride release glass ionomer cement & a mixture of anti-bacteria drug mainly metronidazole. The newly developed restorative material was tested for compressive strength, surface hardness, surface solubility, fluoride release, fluoride uptake for enamel and dentin, acid resistance of the tooth structures and it's anti-bacterial effect.The following results were obtained ;The sustained fluoride release from the newly developed restorative material was observed up more to 2 months period. The anti-bacterial sustained effect of newly developed restorative material, did not had big change on the material but was weaked, but sufficiently for restoration. Analysis material-enamel and dentin interface using an electron probe x-ray microanalyzer showed the fluoride uptake for enamel and dentin wall areas on contact parts with the fluoride releasing experimental materials. The test of acid resistance was by comparing the amount of dissolved calcium from enamel and dentin specimens in contact with experimental materials for 2 months ; it showed that there were smaller amount than those in contact with without-fluoride release materials sample(kept in deionized water or non-fluoride release materials). The acid resistance of fluoridated enamel and dentin specimens by experimental fluoride releasing materials was increased. From this study, it was confirmed that the newly developed restorative material is useful to root caries of elderly and it could prevent primary or sccondary caries.