The Histological Study of Ridge-augmentation by Using Guided Tissue Regeneration

利用引导组织再生进行嵴增高的组织学研究

• 批准号: 08672210
• 负责人: TSUTSUMI Koji
• 金额: $ 1.41万
• 依托单位: KANAGAWA DENTAL COLLEGE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08672210/
• 关键词: GUIDED BONE REGENERATION; rod rainforcement collagen membrane; standardized radiograph; digital subtraction; Guided Bane Regeneration; 歯槽堤増大; 形態付与性; 吸収性膜; サブトラクション

Guided Bone Regeneration (GBR) is demenstrated that is useful in ridge augmentation, but so that materials which is used with GBR is non-absorbable, those problems of infection with membrane exposure and the second operation of materials removal had been indicated.So the purpose of this study is to examine possibility of ridge augmentation in bone defects, with we develop absorbable membrane having take form, and using it in dog bone defect model.Bilateral mandibular first molars had been extracted 3 months previously and this study was started. After edentulous part gingiva was incised and buccal mucoperiosteal flaps were raised to ward the lingual side to expose bone, buccal and lingual bone wall segments measuring 5mm*5mm were removed to form bone defects, continuous bucco-lingually.The experimental group coated bone defects by rod reinforcement collagen membrane as can get space of approximately 5 mm high and the control group did only reposition suture of gingival flap.Periapical … More radiographs were obtained with individually manufactered bite blocks and the long-cone technique and fixed photography condition in right after operation and after an operation 12 weeks. There in right after operation/after an operation 12 weeks radiographs were evaluated analysis by Subtraction.We made mesiodistal serial sections according to universal law and there were stained for histopathological examination.The variate of circumference original alveoler bone of experiment parts was recognized much in control group and regeneration volume in experiment parts was recognized much in experimental group for radiographs.Concavity recognized alveoler bone much in control group and bone regeneration that original alveoler bone crest was shifted to flatly was recognized in experimental group for histopathological findings.boundary part of neogenesis bone and original alveoler bone was indistinctness relatively.The remain of collagen membrane was hardly recognized and the inflammatory cells wasn't observed in circumference of membrane setting part in experimental group. Less

为了探讨引导骨再生(GBR)在骨缺损修复中应用的可行性，研制了可吸收膜，并将其应用于犬双侧第一磨牙骨缺损模型。无牙牙部切开后，将颊粘骨膜瓣抬起至舌侧露骨，切除颊、舌侧5 mm×5 mm的骨壁，形成骨缺损区，沿颊舌向连续，实验组用棒状增强胶原膜覆盖骨缺损区，可获得约5 mm高的间隙，对照组仅进行牙龈瓣再定位缝合。根尖周膜…在术后即刻和术后12周，采用自制咬合块和长锥体技术，固定摄片条件，可获得较多的X线片。术后即刻/术后12周摄片，减影分析。按一般规律制作近远端连续切片，染色进行组织病理学检查。对照组实验区原始牙槽骨周长变化较明显，实验组实验区再生体积较大。对照组空洞较多识别牙槽骨，实验组组织病理学观察可见原始牙槽骨骨顶平移，新生骨与原始牙槽骨边界不清，胶原膜残留较少，有炎性细胞存在实验组贴膜部周边未见明显改变。较少

项目成果

DAISUKE KITSUGI: "THE EFFECT OF EXTRACTION ALVEOLUS HEALING BY ATERO-COLLAGEN SPONGEIMPRANTATION." JOURAL OF JAPANESE SOCIETY OF ORAL IMPLANTOLOGY. VOL10, No4. 444-453 (1997)

DAISUKE KITSUGI：“通过 ATERO 胶原蛋白海绵植入来愈合拔牙肺泡的效果。”

木次大介 他6名: "アテロコラーゲンスポンジの抜歯窩治癒過程に及ぼす効果について" 日本口腔インプラント学会誌. 10巻4号. 444-453 (1997)

Daisuke Kiji 等 6 人：“去端肽胶原海绵对拔牙槽愈合过程的影响”，日本口腔种植学会杂志，第 10 卷，第 444-453 期（1997 年）。

木次 大介他6名: "アテロコラーゲンスポンジの抜歯窩治療過程に及ぼす効果について" 日本口腔インプラント学会誌. 10巻4号. 444-453 (1997)

Daisuke Kiji 等 6 人：“去端肽胶原海绵对拔牙窝治疗过程的影响”日本口腔种植学会杂志，第 10 卷，第 444-453 期（1997 年）。

KODAMA TOSHIRO: ONE STAGE GUIDED TISSUE REGENERATION SYSTEM.PRACTICE OF USING BIODEGRADABLE BARRIER MEMBRANE.IGAKUJYOUHOUSYA, (1996)

KODAMA TOSHIRO：一级引导组织再生系统。使用生物可降解屏障膜的实践。Igakujyouhousya，（1996）