PENETRATION OF ANTIBIOTICS INTO ORAL TISSUE TO DIABETIC DESEASE

抗生素渗透到口腔组织导致糖尿病

• 批准号: 08672340
• 负责人: SANGU Yoshikuni
• 金额: $ 0.7万
• 依托单位: TOKYO WOMEN'S MEDICAL COLLEGE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08672340/
• 关键词: DIABETIC DISEASE; TOOTH EXTRACTION; MICROCIRCULATORY DISORDERS; ANTIBIOTICS; INTO ORAL TISSUE; TISSUE PENETRATION; 移行濃度

The fact that diabetics are susceptible to infections and worsening of periodontal disease is common knowledge, and in the routine clinical practice of oral surgery antibacterial agents should always be administered whenever diabetics are subjected to invasive oral treatment, such as tooth extraction. However, it is thought that microcirculatory disorders develop in diabetics in association with the progression of diabetic microangiopathy in the capillaries of the oral mucosa, the same as in the retina, and thus it was predicted that the concentrations of antibacterial agents that penetrate the oral mucosa would be lower than in healthy persons. The subjects of this study were diabetics who were examined in the oral surgery department of Tokyo Women's Medical College and underwent tooth extraction. Oral antibacterial agents were administered to them, blood and gingiva specimens were collected during the procedure, and the concentrations of the antibacterial agents in the serum and ging … More iva were measured by bioassay. The results of measuring concentrations of cefacrol in 35 patients and lomefloxacin hydrochloride in 30 patients have been obtained this far. The values for cefacrol in the gingiva within 1 h after ingestion were : maximum, 1.67mug/g ; minimum, 0.09mug/g ; mean, 0.828(]SY.+-。[)0.500mug/g ; between 1 and 2 h after oral administration the values were : maximum, 7.98mug/g ; minimum, 0.4mug/g ; and mean, 2.038(]SY.+-。[)1.691mug/g. When lomefloxacin hydrochloride was administered to the diabetics, the serum concentration was 0.22-1.97mug/ml and the gingival concentration was 0.20-2.93mug/ml and the serum of wound after extraction concentration 0.30-3.04mug/ml, as opposed to a serum concentration of 0.47-3.76mug/ml and a gingival concentration of 0.13-2.00mug/g and the serum of wound after extraction concentration of 0.24-2.65mug/g in the healthy subjects. However, none of the differences between them were significant. A larger series of cases and a more detailed study will be needed in the future. Less

糖尿病患者易受感染和牙周病恶化的事实是常识，并且在口腔外科的常规临床实践中，每当糖尿病患者经受侵入性口腔治疗（例如拔牙）时，都应始终施用抗菌剂。然而，认为糖尿病患者的微循环障碍与口腔粘膜的毛细血管中的糖尿病微血管病的进展相关，与视网膜中的情况相同，因此预测穿透口腔粘膜的抗菌剂的浓度将低于健康人。本研究的对象是在东京女子医科大学口腔外科接受检查并进行拔牙的糖尿病患者。给他们口服抗菌药物，并在手术过程中收集血液和牙龈标本， ...更多信息 通过生物测定法测定IVA。对35例病人的头孢克罗和30例病人的盐酸洛美沙星进行了血药浓度测定。摄入后1小时内牙龈中的头孢克罗值为：最大值，1.67 μ g/g ;最小值，0.09 μ g/g ;平均值，0.828（]SY.+-. [）0.500 μ g/g ;口服给药后1 - 2小时的值为：最大值，7.98 μ g/g ;最小值，0.4 μ g/g ;平均值，2.038（]SY. ±-。[）1.691 μ g/g。糖尿病患者口服盐酸洛美沙星时，血药浓度为0.22- 1.97 μ g/ml，牙龈血药浓度为0.20- 2.93 μ g/ml，创面血药浓度为0.30- 3.04 μ g/ml，与0.47- 3.76 μ g/ml的血清浓度和0.13- 2.00 μ g/g的牙龈浓度以及0.24- 2.65 μ g/g的伤口提取后的血清浓度相反，g在健康受试者中。然而，它们之间的差异都不显著。今后将需要更多的案例和更详细的研究。少