Disialosyl galactosyl globoside as an adhesion molecule expressed on renal and lung cancer cells and its relationship to adrenal gland metastatic potential

1)肾细胞癌肾上腺转移：肾上腺切除术的意义：对1977 ~ 1996年在东北大学医院行肾切除术的肾细胞癌患者256例进行肾上腺转移调查。肾上腺转移的风险与T分类、分级和肿瘤位置无关。肾上腺被认为是肾细胞癌扩散的“肥沃土壤”。（j.j urrol）2)建立了4个新的表达gloo系列神经节苷脂的人肾细胞癌细胞系：来源于人肾细胞癌组织的TOS-1、TOS-2、TOS-3和TOS-3LN细胞系。这些细胞系显示出不同的globo系列神经节苷脂表达模式。（东北实验医学杂志，1989,95 -105,1999。）3)肾细胞癌（RCC）抗原双烯丙基半乳糖苷（DSGG）与表面膜聚集域c-Src和Rho A的关联：DSGG在RCC中聚集形成一个微域，与c-Src、Rho A和FAK密切相关，可能构成一个功能单元。这些单位的功能组织可能是决定RCC细胞恶性性质所必需的。[J] .中华医学杂志，2004,31(4):387 - 398。4)DSGG介导RCC和肺癌细胞对肾上腺髓质靶细胞的粘附：表达DSGG的RCC或肺癌细胞系对肾上腺组织具有较强的粘附性。这种粘附过程可能引发肾上腺优先转移。（ayumi: 194,841 -844,2000）

1)Adrenal metastasis from renal cell carcinoma : significance of adrenalectomy :Adrenal metastases were investigated in 256 patients with RCC undergone nephrectomy from 1977 to 1996 in Tohoku University Hospital. The risk of adrenal metastasis did not correlate with T classification, grade, and tumor location. The adrenal gland was thought to be a "fertile soil" for spread of renal cell carcinoma. (Int J Urol. under revision)2)Establishment of 4 new human renal cell carcinoma cell lines expressing globo-series ganglioside:TOS-1, TOS-2, TOS-3 and TOS-3LN cell lines derived from human RCC tissues were established. These cell lines showed different expression pattern of globo-series ganglioside. (Tohoku J Exp Medicine : 189,95-105,1999.)3)Association of renal cell carcinoma (RCC) antigen, disialylgalactosylgloboside (DSGG), with c-Src and Rho A in clustered domains at the surface membrane :DSGG is clustered in RCC to form a microdomain in which it is closely associated with c-Src, Rho A and FAK and may constitute a functional unit. The functional organization of such units may be essential in determining malignant properties of RCC cells. (Int J Oncol : 16,529-536,2000.)4)DSGG mediates adhesion of RCC and lung cancer cells to certain adrenal medulla target cells :DSGG expressed RCC or lung cancer cell lines showed strong adhesion to adrenal gland tissues. This adhesion process may initiate preferential adrenal metastasis.(IGAKU NO AYUMI : 194, 841-844,2000)