Transcriptional regulation of rhodopsin gene under light dark cycle

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The signal pathway transcriptional regulation of rhodopsin gene under light dark cycle was investigated. The oligo nucleotide of the promoter cite of the rhodopsin ran slower in the gel retardation assay when incubated with the nuclear extract of the retina, suggesting that there are something in the nucleus of the retina that bind the site.In addition, the oligo nucleotide ran even slower when incubated with anti-c-Fos antibody and the nuclear extract of the retina, suggesting that c-Fos protein in the retina bind the promoter cite of the rhodopsin gene. We are now eramining the role of the c-fos gene in the transcriptional regulation of the rhodopsin in vivo by using c-fos knockout mice.