Studies on Synthesis of Phospha-sugars by a New Route and Their Enzyme Inhibition

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A New Route for Preparation of Pyranose-type Phospha-sugars.D-gluco and L-idopyranose phospha-sugars were prepared in 6 steps, by starting with 3, 6-di-O-benzyl-1, 2-O-isopropylidene-α-D-xylo-hexofuranos-5-ulose.2. Synthesis of D-Galactopyranose Phospha-sugar.D-galactopyranose phospha-sugar was prepared in 6 steps, by starting with 3, 6-di-O-benzyl-1, 2-O-isopropylidene-β-L-arabino-hexofuranos-5-ulose.3. Synthesis of D-mannosamine Phospha-sugar.3, 6-Di-O-benzyl-5-O-deoxy-5-dimethylphosphinyl-1,2 O-isopropylidene-α-D-glucofuranose was converted, in 4 steps, into methyl 2-acetamido-3, 6-di-O-benzyl-2, 5-dimethoxyphosphinyl-α-D-mannofuranoside, which led to 3, 5-di-O-benzyl derivatives of D-mannosamine phospha-sugar.4. The effect of a Phosphorus Atom upon Vicinal ィイD11ィエD1H-ィイD11ィエD1H Coupling Constants in Phospha-sugars.Additivity constants for phosphorus were estimated for the prediction of vicinal ィイD11ィエD1H-ィイD11ィエD1H coupling constants by means of an additivity rule in a series of pyranose-type phospha-sugars.