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Fundamental study on diffusing light topography

漫射光形貌的基础研究

基本信息

批准号：
10650396
负责人：
IWAI Toshiaki
金额：
$ 2.24万
依托单位：
HOKKAIDO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10650396/
关键词：
Diffusing light topogaphy Multiple backscattering Monte Carlo simulation Photon diffusion theory Optical path-length distribution Optical CT Visualization of blood vessel Deconvolution 拡散光トポグラフィ血管造影

项目摘要

The purpose of the research project is to establish a diffusing light topography in a surface profiling of an absorber embedded in a strongly scattering medium. The relation between a backscattered intensity distribution and an optical path-length distribution was first studied by means of Monte Carlo simulations. The fairly well images for a slab-plane, stir-like, and modified-pyramidal absorbers were reconstructed in experiments and simulations and, therefore, the availability of the proposed method was confirmed. The deconvolution method was introduced to the formation of the backscattered intensity distribution at the boundary to improve the quality of the blurred image. A portion of the edge in the blurred image was sharpened by using the point spread function estimated by the Monte Carlo simulation for the point-like absorber placed at the shallowest depth. Finally, the optical path-length distribution was derived theoretically from a photon diffusion equation. The new relation between the depth of the absorber and the maximum path-length was obtained, by which the image was reconstructed with the same accuracy as the simulation. Throughout this research project, we are convinced that the proposed diffusing light topography leads us to the visualization of the blood vessel map and the tumor under the skin.

本研究的目的是建立一个漫射光形貌在一个表面轮廓的吸收体嵌入在一个强散射介质。首先，通过蒙特卡罗模拟来研究后向散射强度分布与光程长度分布之间的关系。实验和仿真结果表明，该方法对平板、搅拌式和修正金字塔形吸波体的成像效果较好，验证了该方法的有效性。将反卷积方法引入到边界处后向散射强度分布的形成中，以改善模糊图像的质量。模糊图像中的边缘的一部分，锐化通过使用点扩散函数估计的蒙特卡罗模拟的点状吸收体放置在最浅的深度。最后，从光子扩散方程出发，从理论上推导了光路长度分布。得到了吸收体深度与最大光程之间的关系式，并利用该关系式重建了与模拟结果相同精度的图像。在整个研究项目中，我们确信所提出的漫射光拓扑结构使我们能够可视化皮肤下的血管图和肿瘤。