Host Selection of Anti-tumor Basidiomycetes meshimakobu (Phellinus linteus) for yamaguwa (Morus bombycis).

山木被誉为日本最耐腐的木材之一。抗肿瘤蘑菇“meshimakobu”通常存在于这种山形木材中。我们试图弄清楚mesimakobu选择yamaguwa作为宿主木材的原因。mesimakobu在yamaguwa木材中的菌丝生长比kunugi和konara木材更促进。就甘露菌、川原菌和香菇而言，它们在山口木中的生长受到抑制。结果发现，山根的热水提取物含有对目岛光的促进剂，而甲醇提取物含有对其他木材腐烂真菌的抑制剂。山根的甲醇提取物的苯酚部分对除目岛光之外的木材腐烂真菌表现出更强的抗真菌活性。氧化白藜芦醇被认为是山川甲醇提取物的酚级分中的主要抗真菌因子。然而，Meshimakobu 非常弱，即使在培养基中添加氧化白藜芦醇，也很容易被其他木材腐烂真菌击败。从这些结果看来，Meshimakobu 只能在山口勉强存活，因为抗真菌因子氧化白藜芦醇显着阻止了其他强木材腐烂真菌的生长。

Yamaguwa is well known as one of the most durable wood for decay in Japan. Anti-tumor mushroom, meshimakobu is found typically in this yamaguwa wood. We attempted to clear the reason why mesimakobu selects yamaguwa as a host wood.The mycerial growth of mesimakobu in yamaguwa wood was promoted more than kunugi and konara wood. In the case of mannentake, kawaratake and shiitake, their growth were depressed in yamaguwa wood. It was found that a hot water extracts of yamaguwa contained a promoter for meshimakobu and methanol extracts contained inhibitors for other wood rotting fungi.The phenol fraction of methanol extracts of yamaguwa showed greater antifungal activities for wood rotting fungi, other than meshimakobu. Oxyresveratrol was presumed as a main antifungal factor in a phenol fraction of methanol extracts of yamaguwa. Meshimakobu was however very weak and easily defeated by other wood rotting fungi even when oxyresveratrol was added in a culture medium.From these results, it seems that meshimakobu could be barely survived only in yamaguwa because antifungal factor, oxyresveratrol prevented significantly the growth of other strong wood rotting fungi.