Protective effects of Lycopene on hepatocarcinogenesis in Long-Evans Cinnamon rats

据报道，在长埃文斯肉桂（LEC）中存活很长时间的高发病率肝炎结肠癌细胞（HCC）。在订购对Lycopene和Sho-saiko-to（TJ-9）进行了抗葡萄球菌、Lycopene和TJ-9的调查后，对LEC大鼠进行了一年半的管理，并研究了对这些大鼠自然葡萄球菌的影响。所有的老鼠在76周的生命中都被净化了，进行了自动化和历史学测试。控制老鼠患有HCC的55%（1/20），55%（11/20），TJ-9组患有HCC的75%（12/16）。吃HCC的老鼠的百分比在这三个群体之间没有区别。Number of preneoplastic lesions stained with GST-P per lcm D12的liver specimen was smaller in Lycopene group with control group比较（p = 0.00124）。利可普烯组中的铁离子浓度与TJ-9组相比（p=0.0207）。关于铁剥夺也抑制了肝脏肿瘤的发展的报告，发现了与Lycopene组中较低的铁离子浓度与TJ-9组有可能与GST-P. Serum α-fetoprotein水平的较低数量的预塑性脂蛋白水平在控制组（n=9）中的331.0 ± 249.1纳克/毫升之间有一定的联系，Lycopene组中的559.4 ± 1211.4纳克/毫升（n=11）和TJ-9组中的5883 ± 653.4纳克/毫升（n=11）。血清α-雌激素水平在三个群体之间没有区别。在整合中，反Hepatocarcinogenesis在Lycopene和TJ-9中没有引起。进一步的研究将需要澄清Lycopene对预塑料问题的预防性影响。

A high incidence of hepatocellular carcinoma (HCC) in long surviving Long Evans Cinnamon (LEC) rats was reported. In order to investigate whether Lycopene and Sho-saiko-to (TJ-9) have anti-hepatocarcinogenesis, Lycopene and TJ-9 were administered orally for one and a half years in LEC rats and studied the effect to natural hepatocarcinogenesis of these rats. All rats were sacrificed in 76 week life for autopsy and histopathological examination was performed. Fifty five percent (1 1/20) of control rats had HCC, 55% (11/20) of Lycopene group had HCC, and, 75% (12/16) of TJ-9 group had HCC in 76 week life. Percentage of HCC bearing rats did not differ among the three groups. Number of preneoplastic lesions stained with GST-P per lcmィイD12ィエD1 of the liver specimen was smaller in Lycopene group compared with control group (p = 0.00124) . Concentration of iron ion in the liver of Lycopene group were lower compared with TJ-9 group (p=0.0207). Concerning the report that iron deprivation also inhibited the liver tumor development, the finding of lower concentration of iron ion in the liver of Lycopene group compared with TJ-9 group has a possibility to have some link to the result of lower number of preneoplastic lesions stained with GST-P. Serum α-fetoprotein levels were 331.0 ± 249.1 ng/ml in control groups (n=9), and 559.4 ± 1211.4 ng/ml in Lycopene group (n=11), and 5883 ± 653.4 ng/ml in TJ-9 group (n=11). There were no differences in serum α-fetoprotein levels among the three groups. In conclusion, anti-hepatocarcinogenesis were not foud in Lycopene and TJ-9. Further study will be needed to clarify the preventive effect of preneoplastic lesions by Lycopene.