Clinical Utility of Information of Metabolite Diffusion, Concentration and Relaxation Time Evaluated by Multiple Parametric Analysis

多参数分析评估代谢物扩散、浓度和弛豫时间信息的临床实用性

• 批准号: 10670854
• 负责人: NISHITANI Hiromu
• 金额: $ 2.11万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670854/
• 关键词: MR spectroscopy; concentration; diffusion; relaxation time; multiple parametric analysis; Proton MRS; 因子分解; 脳腫瘍

We measured intra-cerebral metabolites by proton MR spectroscopic method using a clinical MR instrument and evaluated metabolite concentration, metabolite diffusion and relaxation time. Each parameter was estimated by multi-parametrci analysis including multiple analysis of covarience (MANCOVA) and factor analysis, and clinical utility of each metabolite parameter was discussed.1) Aging change of metabolite concentration in the normal brain :The NAA concentration in the oldest age group (60s- year) showed marked difference between two measurement portions(post-hoc tests : P<0.01). Cr and Cho were seemed not to change with aging. The result of statistical analysis was conducted using ANOVA and ANCOVA. This revealed the remarkable aging difference of NAA concentration on the lenticula but no statistical difference of NAA on the frontal lobe. The Cr concentration showed no significant difference in the five age groups on the both locations, and the Cho concentration on the lenticula had m … More edium significant probability of statistical difference in the five groups. MANCOVA was conducted to compare the correlation in aging change of each metabolite and the cerebral regions. A significant interaction(P<0.01) between aging change of NAA and the cerebral regions, thereby indicating that the change in NAA concentration with age was different deponding on the cerebral region.2) Metabolic difference of cerebral region with autistic patientsThe relaxation times of patients and controls were shown in Table and no significant difference was found between two groups (P>0.1) , The typical MR spectra of temporal lobe between patients and controls showed slight difference. The increasing tendency of NAA concentration was found even in the temporal lobe of patients, but is was significant different from that of normal controls depending on each age. By multiple statistical comparison, the aging change of NAA concentration of autistic patients were different depending on the cerebral region, and those in the temporal lobe and parietal lobe were significant different (P<0.05) from that of normal controls in the same region. However the NAA changes in other cerebral regions did not show any statistical difference between patients and controls. Because NAA concentration could be a neuronal marker, this result may suggest low neuronal density or neuronal dysfunction in the temporal lobe and parietal lobe of autism and might indicate the cause of language disorder in autism.We considered that NAA concentration and diffusion status changed depending on normal aging and pathological changed would exceed the normal aging variation even when anatomical imaging shows no abnormal finding. The multiple parmaetric analysis will offer the clinical judgement and threshold between normal aging and pathological changes. Less

我们使用临床MR仪器通过质子MR波谱方法测量脑内代谢物，并评估代谢物浓度、代谢物扩散和弛豫时间。采用多元协方差分析（MANCOVA）和因子分析等多参数分析方法对各代谢物参数进行估计，并对各代谢物参数的临床应用价值进行探讨。1）正常脑代谢物浓度的增龄变化：最大年龄组（60岁）的NAA浓度在两个测量部位之间有显著性差异（事后检验：P <0.01）。Cr和Cho似乎不随增龄而变化。统计分析结果采用方差分析和协方差分析。结果表明，小脑NAA含量的年龄差异显著，而额叶NAA含量的年龄差异不显著。两个地点五个年龄组的Cr浓度无显著差异，透镜体上的Cho浓度有显著差异。 ...更多信息 五组间差异有统计学意义。采用MANCOVA分析比较各代谢产物的增龄变化与脑区的相关性。交互作用显著NAA的增龄变化与脑区的变化有显著性差异（P <0.01），说明不同脑区NAA浓度随年龄的变化不同。2）孤独症患者脑区代谢的差异颞叶典型MR波谱与正常对照组无显著性差异（P> 0.1）。患者颞叶NAA浓度也有增高的趋势，但各年龄组与正常对照组比较差异有显著性。经多重统计学比较，孤独症患者不同脑区NAA浓度的增龄变化不同，颞叶和顶叶与同脑区正常对照组相比差异有显著性（P <0.05）。而其他脑区的NAA变化在两组间无统计学差异。由于NAA浓度可能是一种神经元标记物，提示孤独症患者颞叶和顶叶神经元密度降低或功能障碍，提示孤独症患者语言障碍的原因，我们认为NAA浓度和扩散状态的变化依赖于正常的年龄，即使解剖影像学无异常发现，病理变化也会超过正常的年龄变化。多参数分析可为临床判断正常衰老与病理变化提供依据和阈值。少

项目成果

M.Harada,H.Nishitani,et al.: "Neuronal impairment of adult moyamoya disease detected by quantified proton MRS"Journal of Magnetic Resonance Imaging. 10. 124-129 (1999)

M.Harada、H.Nishitani 等人：“通过量化质子 MRS 检测成人烟雾病的神经损伤”磁共振成像杂志。

H.Otsuka,M.Harada,K.Mori et al.: "Brain metabolites in the hoppocampus-amydala region and cerebellum in antism"Neuroradiology. 41. 517-519 (1999)

H.Otsuka、M.Harada、K.Mori 等人：“抗抑郁症中海马-杏仁核区域和小脑的脑代谢物”神经放射学。

H. Otsuka, M. Harada, K. Mori, H. Nishitani, et al.: "Brain metabolites in the hippocampus-amydala region and cerebellum in autism"Neuroradiology. Vol. 41. 517-519 (1999)

H. Otsuka、M. Harada、K. Mori、H. Nishitani 等人：“自闭症患者海马-杏仁核区域和小脑的脑代谢物”神经放射学。

原田雅史、西谷弘 他: "脳梗塞急性期における水拡散能と代謝の変化"臨床放射線. 44(11). 1353-1360 (1999)

Masashi Harada、Hiroshi Nishitani 等：“脑梗塞急性期水扩散率和代谢的变化”临床放射学 44(11) (1999)。

M. Harada, K. Mori, H. Nishitani, et al.: "Diffusion status and lactate production with different post-infectious encephalopathy"JMRI. (in press).

M. Harada、K. Mori、H. Nishitani 等人：“不同感染后脑病的扩散状态和乳酸产生”JMRI。