The mechanism of c-fos expression on destruction of bone and cartilage in rheuamtoid arthritis

本研究表明，人软骨细胞c-fos的表达导致内源性II型胶原转录减少，基质蛋白酶及其抑制剂之间的不平衡。组织学研究表明，c-fos在类风湿性关节炎患者的软骨细胞中表达增加，但在骨关节炎患者中不表达。因此，c-fos可能是最有潜力的候选人之一，在类风湿关节炎软骨破坏的发病机制中起着至关重要的作用。进一步研究c-fos表达的调节可能为预防类风湿关节炎患者关节破坏提供一种有效的方法。

The present study shows that expression of c-fos in human chondrocytes results in the decrease of endogenous transcription of Type II collagen and the inequality between matrix protease and their inhibitors. Histopathological studies indicates that the expression of c-fos is increased in chondrocytes from patients with rheumatoid arthritis, but not in those with osteoarthritis. Thus, c-fos could be one of the most potential candidates which play a crucial role in the pathogenesis of cartilage destruction in rheumatoid arthritis. Further studies examining the modulation of c-fos expression may provide an effective approach to prevent joint destruction in rheumatoid arthritis patients.