BASIC STUDY FRO IMMUNOLOGICAL ABNORMALITIES SUCH AS NATURAL KILLER CELL ACTIVITY IN THE UTERINE ENDOMETRIUM IN PATIENTS WITH RECURRENT MISCARRIAGES

在6名患者中，2名或2名以上未经解释的自发性人工流产和16名女性人工流产（控制）已被分析的妇女。一个潜在的流产引起的案例，由异常胚胎K型从分析中排除。Lymphocytes were separated from each decidual tissue and CD D116+56+ 3-D1 cells were measured。There was no difference of CD D116+56+ 3-D1 cells between patients and controls。宏观系统也与6个病人和5个控制的决定性问题分开，TGF-β被测量。两个群体之间没有区别，我们在临床上确定，无论是一种杀死的链球菌准备，还是一种生物反应修改器，它就像一种有效的专利淋巴细胞免疫疗法，用于无法解释的经常性自发性堕胎疗法。研究组的成功率为73.9%（17/23），与控制（不显著）相比为75%（254/205）。最成功的案例中，NK细胞在外周血中的活性水平较低。某些免疫性调节机制对NK细胞活性的抑制也在成功怀孕结果的条件下找到了潜在的好处，NK细胞活性也与精神紊乱有关。这已经被报道说，压力会导致死亡流产。我们研究了29对有两对不幸的夫妇的心理学因素。“第二个错误对两个妇女及其伙伴造成了明显的更消极的影响。”我们还发现了低神经学、低抑郁量表分数和高自我谴责为61名女性中的高NK活动做出的贡献。

Decidual tissue of abortus in 6 patients with unexplained two or more consecutive spontaneous abortion and 16 women with artificial abortion (control) were analyzed. Cases with spontaneous abortion caused by abnormal embryonal karyotype were excluded from analysis. Lymphocytes were separated from each decidual tissue and CDィイD116+56+3-ィエD1 cells were measured. There was no difference of CDィイD116+56+3-ィエD1 cells between patients and controls. Also macrophages were separated from decidual tissue of 6 patients and 5 controls and TGF-β was measured. There was no difference between two groups.We determined clinically whether a killed streptococcal preparation, a biological response modifier, is as effective as paternal lymphocyte immunotherapy for unexplained recurrent spontaneous abortion therapy. The success rate in the study group was 73.9% (17/23), compared to 75% (254/205) observed for the controls (not significant). Most of the successful cases exhibited low levels of NK cell activity in the peripheral blood. Suppression of NK cell activity by some immunoregulatory mechanism was also found to have potential benefit in terms of a successful pregnancy outcome.NK cell activity is also associated with mental disorder. It has been reported that stress induce murine abortion. We studied psychosocial factors in 29 couples with two miscarriages. The second miscarriage had a significantly stronger negative impact than the first for both women and their partners. We also found that low neuroticism, low depression scale score and high self-esteem contributed to high NK activity among 61 women with patients.