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Change of motor supply following the laryngeal nerve injury

喉神经损伤后运动供应的变化

基本信息

批准号：
10671625
负责人：
YOSHIDA Tetsuji
金额：
$ 2.05万
依托单位：
Kurume University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

项目摘要

So as to confirm how to relay information of the central nervous system to the laryngeal motoneurons in the brainstem, the laryngeal dendritic arborization and the contact between the related interneurons and dendrites were studied morphologically. 1. Dendrites of the cricothyroid muscle extended widely, except in dorsolateral direction, and most dendrites of its cell column extended rostrally rather than caudal. The pattern of dendritic architecture of posterior cricoarytenoid motoneurons differed from those of other intrinsic laryngeal motoneurons. Dendrites of the abductor motoneurons stretched mainly dorsomedially to the dorsal respiratory group and ventrolaterally to respiratory neurons located in the ventral respiratory group. In addition, many dendrites in caudal region of its cell column were observed extending more caudally to the nucleus retroambigualis, which contains inspiratory neurons in the rostral part of nucleus. A the other hand, dendrites for the adductor extended in … More dorsomedial, ventromedial and ventrolateral directions. In the rostral portion of the adductor cell columns, dendrites stretched mainly dorsomedially and ventromedially toward swallowing interneurons in the reticular formation surrounding the nucleus ambiguus. Furthermore, some dendrites of the rostral adductor cell columns were found extending to the Botzinger complex, which is related as a respiratory center. Systematic observation of the dendritic architecture of intrinsic laryngeal motoneurons has not been reported previously. The present results suggest that extent of dendrites for each laryngeal motoneurons has properties for laryngeal function. 2.To clarify connection between laryngeal dendrites and related interneurons in the medulla oblongata, Fos-immunohistochemistry was performed. The presence of neurons of the lower brainstem, that respond to the internal branch of superior laryngeal afferent electrical stimulation, was investigated by double labeling. The subjects having less than nine microsecond latency to respond glottic closure after stimulation, indicated the existence of one or two neurons between the nucleus of solitary tract (NTS) and the nucleus ambiguus (NA). Interneurons were seen in surrounding NTS, ventral to NTS and reticular, formation close to NA, and also were seen touching with the adductor dendrite. The laryngeal reflex pathway under short latency was consider as fundamental organization of protection of the airway in larynx. Less

为了明确脑干内喉运动神经元如何传递中枢神经系统的信息，我们对喉树突分支及其相关中间神经元与树突的接触进行了形态学研究。1.环甲肌的树突除背外侧外广泛延伸，其细胞柱的树突大多向吻侧而非尾侧延伸。环杓后肌运动神经元的树突结构与其他喉内运动神经元的树突结构不同。外展肌运动神经元的树突主要向背内侧伸展到背侧呼吸组，向腹外侧伸展到腹侧呼吸组的呼吸神经元。此外，在其细胞柱的尾侧区还观察到许多树突向尾侧延伸至疑后核，疑后核的吻侧部含有吸气神经元。内收肌的树突则向内侧延伸 ...更多信息背内侧、腹内侧和腹外侧方向。在收肌细胞柱的吻侧部分，树突主要向背内侧和腹内侧延伸，朝向吞噬疑核周围网状结构中的中间神经元。此外，一些树突的嘴侧收肌细胞柱被发现延伸到Botzinger复合体，这是相关的呼吸中枢。系统观察喉内运动神经元的树突状结构尚未见报道。本研究结果提示，喉运动神经元树突的数量与喉功能有关。2.应用Fos免疫组织化学方法研究喉树突与延髓内相关中间神经元的联系。双标记法研究了对上级喉传入电刺激的内分支有反应的下脑干神经元的存在。刺激后声门闭合反应的潜伏期小于9微秒的受试者，表明孤束核（NTS）和疑核（NA）之间存在一个或两个神经元。中间神经元分布于孤束核周围、孤束核腹侧和靠近NA的网状结构中，并与内收肌树突接触。短潜伏期喉反射通路被认为是喉内气道保护的基本组织。少