Comparative study of Tc-99m and Ga-67 scintigraphy in oral squamous cell carcinoma with doubted mandibular invasion. - Mandibulectomy cases -

Tc-99m 和 Ga-67 闪烁扫描在疑似下颌侵犯的口腔鳞状细胞癌中的比较研究。

• 批准号: 10671902
• 负责人: SEGAWA Kiyoshi
• 金额: $ 0.26万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671902/
• 关键词: oral squamous cell carcinoma; mandibulal invasion; ィイD199mィエD1Tc-scintigraphy; ィイD167ィエD1Ga-scintigraphy; recurrence; prognosis; ^<99m>Tcシンチグラフィ; ^<67>Gaシンチグラフィ; 腫瘍シンチグラフィー; 骨シンチグラフイー; 手術

Mandibular invasion caused by oral squamous cell carcinoma is usually detected by roentogenography, computed tomography, and magnetic resonance imaging. In detected and/or suspected cases of invasion of the mandible, Tc-99m (ィイD199mィエD1Tc) scintigraphy is useful in clarifying the extent of the mandibular invasion of the tumor, when used in conjunction with Ga-67 (ィイD167ィエD1Ga) scintigraphy evaluation of possible tumor activity.From 1989 to 1997, twenty-four patients with oral and/or central squamous cell carcinoma suspected of invading the mandible were investigated with ィイD199ィエD1mTc and ィイD167ィエD1Ga scintigraphy. Sites of tumor were; 14 lower gingivae, 3 buccal mucosae, 3 mouth floors, 4 central carcinomas of the mandible. Surgical procedures included; marginal mandibulectomy (n=11), segmental mandibulectomy (n=9), and hemimandibulectomy (n=4). Four recurrent patients had an accumulation of both ィイD199mィエD1Tc and ィイD167ィエD1Ga scintigraphy before treatment. Three patients had undergone marginal mandibulectomy, and one patient received a hemimandibulectomy. Two patients with no histological mandibular invasion had no uptake of ィイD167ィエD1Ga and no roentogenographic bone absorption. Two of four patients with high accumulation of ィイD167ィエD1Ga died of the disease.A comparative study of ィイD199mィエD1Tc and ィイD167ィエD1Ga scintigraphy might improve the possibility for the prediction of tumor reccurence after surgery. In addition, it is useful in determing the best surgical procedure for the mandible.

口腔鳞状细胞癌侵犯下颌骨通常通过X线摄影、计算机断层扫描和磁共振成像来检测。在检测到和/或怀疑下颌骨受侵的病例中，Tc-99m（イD199 m D1 Tc）闪烁扫描与Ga-67联合使用时，可用于阐明肿瘤下颌骨侵犯的程度（荧光D167荧光D1Ga）放射成像评价可能的肿瘤活性。从1989年到1997年，对24名疑似侵犯下颌骨的口腔和/或中央鳞状细胞癌患者进行了イD199 D1 mTc和イD167 D1 Ga闪烁扫描检查。肿瘤部位：下牙龈14例，颊粘膜3例，口底3例，下颌骨中央癌4例。手术包括：下颌骨边缘切除术（n = 11）、下颌骨节段切除术（n = 9）和半下颌骨切除术（n = 4）。4例复发患者在治疗前同时有199mTc和167mTc D1Ga的累积。3例患者接受了下颌骨边缘切除术，1例患者接受了半下颌骨切除术。2例无下颌骨组织学侵犯的患者无骨吸收，X线检查无骨吸收。结果：199mTc-1999mTc-199mTc-1999mTc-199此外，它是有用的，以确定最佳的外科手术程序的下颌骨。

项目成果

Marchetta,C. F., Sako,K., et al.: "The periosteum of the mandibular and intraoral carcinoma."Am J Surg. 122. 711-713 (1971)

马切塔，C.