The relationship between serum Angiostatin levels, tumor angiogenesis and distant metastasis of the oral cancer

本研究为1993-1997年间我科收治的59例口腔鳞癌患者。肿瘤血管生成与远处转移显著相关(p&lt；0.05)，提示肿瘤血管生成可作为远处转移的预测指标。我们在第44届日本口腔颌面外科学会年会(1999)上报道了肿瘤血管生成与转移的关系。组织学恶性程度与转移密切相关。而P53基因、T分期和有无转移之间无显著差异。我们在2000年第45届日本口腔颌面外科学会年会上报道了这一结果。我们不能测量血清血管抑素水平，因为血清纤溶酶原水平很高。林德报告说，尿白蛋白水平和血管抑素之间存在明显的相关性(p=0.003)。我们测定了8例口腔癌患者10例标本的尿白蛋白水平。在发生肺转移的病例中，白蛋白浓度在术前呈高值，术后有所改善。血管生成因子和血管生成抑制因子之间的失衡导致肺转移。

This study was considered 59 patients of oral squamous cell carcinoma who were treated at our department from 1993 to 1997. A significant relation was evident between the tumor an angiogenesis and distant metastasis (p<0.05), indicating that the tumor angiogenesis could be served as a predictor for metastasis. We reported the relationship between tumor angiogenesis and metastasis in 44th annual meeting Japanese society of Oral and Maxillofacial Surgeons (1999). And a significant relation was evident between the degree of histological malignanc and metastasis. However, there was no significant difference between p53 gene, T classification and metastasis. We reported it in 45th annual meeting Japanese society of Oral and Maxillofacial Surgeons (2000). We could not measured serum Angiostatin levels, because serum plasminogen levels were high. Linder reported that a significant relation was evident between urine albumin levels and Angiostatin (p=0.003). We measured urinary albumin levels of the oral cancer 8 cases, 10 samples. In the case which caused lung metastasis, the albumin concentration showed the high value in the preoperation, and it was improved in the postoperation. The imbalance between angiogenesis factor and angiogenesis inhibitor caused lung metastasis.