EPIDEMIOLOGICAL STUDY ON DENTAL STATUS AND TEMPOROMANDIBULAR JOINT IN SUBJECTS WITH RHEUMATOID ARTHRITIS

类风湿性关节炎患者牙齿状况和颞下颌关节的流行病学研究

• 批准号: 10671944
• 负责人: TAKEHARA Tadamichi
• 金额: $ 1.6万
• 依托单位: KYUSHU DENTAL COLLEGE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671944/
• 关键词: RHEUMATOID ARTHRITIS; TEMPOROMANDIBULAR DISORDERS; DENTAL STATUS; 有病者; 高齢者

In order to understand the dental and temporomandibular joint (TMJ) in subjects with rheumatoid arthritis, 142 female patients were compared with 143 control subjects of the same age. The number of remaining teeth and edentulous rate were significantly lower in the RA group than non-RA group. Meanwhile, the number of DMF teeth, as well as frequency of complete denture and removable partial dentures were significantly higher in the RA group. In RA, the incidence of subjective symptoms was 1.4% for pain in the TMJ, 4.9% for pain on mouth opening, and 14.8% for difficulty with mouth opening. Further, signs of TMJ tenderness were found in 9.2%, clicking in 12.7%, and crepitus in 35.9% of those patients. A significantly greater number of subjects who demonstrated crepitus were found in the RA group than the non-RA group. As for temporomandibular disorders (TMD), the incidence was 67.6% in the RA group and 32.9% in the non-RA group. The occurrence of degenerative joint disorders was most frequent among patients with TMD, which was found to correlate with Steinbrocker's stage and RA disease duration.

为了了解类风湿关节炎受试者的牙齿和颞下颌关节 (TMJ) 情况，我们将 142 名女性患者与 143 名同龄对照受试者进行了比较。 RA组的剩余牙齿数量和无牙颌率显着低于非RA组。同时，RA 组的 DMF 牙齿数量以及全口义齿和活动局部义齿的频率显着更高。在RA中，颞下颌关节疼痛的主观症状发生率为1.4%，张口疼痛为4.9%，张口困难为14.8%。此外，9.2% 的患者出现颞下颌关节压痛，12.7% 的患者出现咔嗒声，35.9% 的患者出现捻发音。 RA 组中出现捻发音的受试者数量明显多于非 RA 组。至于颞下颌关节紊乱病（TMD），RA组的发病率为67.6%，非RA组的发病率为32.9%。退行性关节疾病的发生在 TMD 患者中最为常见，这与 Steinbrocker 分期和 RA 病程相关。

项目成果

竹原直道: "九州歯科大学附属病院における顎関節症患者の動向" 「顎関節症-診査・診断・治療のガイドライン」. 報告書 印刷中. (1999)

竹原直道：“九州齿科大学医院颞下颌关节紊乱患者的趋势”“颞下颌关节紊乱 - 检查、诊断和治疗指南”（1999 年）。

Akifusa,S.,Ohguchi,M et al: "Increase in Bcl-2 level promoted by CD40 ligation correlates with inhibition of B cell opoptosis induced by vacuolar trpe H+ ATP ase inhibitor"Exp.Cell Res. 238. 82-89 (1998)

Akifusa,S.、Ohguchi,M 等人：“CD40 连接促进的 Bcl-2 水平增加与空泡 trpe H ATP 酶抑制剂诱导的 B 细胞凋亡抑制相关”Exp.Cell Res。

Chen, X., Ansai, T., Awano, S., Iida, T., Barik, S.and Takehara, T.: "Isolation, cloning, and expression of an acid phosphatase containing phosphotyrosyl phosphatase activity from Prevotella intermedia."J.Bacteriol.. 181. 7107-7114 (1999)

Chen, X.、Ansai, T.、Awano, S.、Iida, T.、Barik, S. 和 Takehara, T.：“从中间普雷沃氏菌中分离、克隆和表达含有磷酸酪氨酰磷酸酶活性的酸性磷酸酶。”

Ansai T.,Tahara A, et al: "Influence of initial colonization of mutans streptococci on caries hazard in Japanese preschool chilren."Pediato.Dent. 22. 377-380 (2000)

Ansai T.、Tahara A 等人：“变形链球菌初始定植对日本学龄前儿童龋齿危害的影响。”Pediato.Dent。

安細敏弘,秋房住郎 他: "口腔分子生物学小事典"口腔保健協会.

Toshihiro Azawa、Sumio Akibusa等：《口腔分子生物学小百科全书》口腔健康协会。