The Relationship between Serum Glufosinate Concentration and Severity of Poisoning Caused by the Ingestion of a Herbicide Containing Glufosin

草铵膦血清浓度与摄入含草铵膦除草剂中毒严重程度的关系

• 批准号: 10672144
• 负责人: KOYAMA Kanji
• 金额: $ 2.11万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10672144/
• 关键词: glofosinate; poisoning; coma; seizure; apnea; herbicide; agricultural chemical

Acute oral poisoning with an berbicide BASTA^<【○!R】> causes consciousness disturbances, convulsions, and apnea after 6-40 hours of ingestion. Because, the patients look non-severe before the onset of these signs, the respiratory management might be late for sever patients. On the other hand, unnecessary intensive treatments such as hemopurifications are sometimes conducted for non-sever patients. For conducting a suitable management for this poisoning, by estimating the severity of this poisoning correctly before the onset of severe signs, we studied serum glufosinate concentration ([GLF]s)and amount ingested(AI)in relation to the severity of the patients.[Method] Ninety-nine cases of BASTA^<【○!R】> ingestion were studied. Fifty-one cases that produced at least one of the following 3 sings : coma, generalized convulsions, and apnea, were defined as severe. Forty-eight cases that produced none of these sings were defined as non-severe. In each case, [GLF]s on admission was measured and AI was estimated. [GLF]s was plotted semi-logarythmically related to the hours after ingestion.[Results][GLF]s of sever cases located higher than those of non-sever cases. All cases aboye the line connecting 210 ppm at 2 hours and 15 ppm at 8 houres were severe. On the contrary, all cases under the line connecting 80 ppm at 2 hours and 5 ppm at 8 hours were non-severe. Between these 2 lines, severe and non-severe cases existed half-and-half. The AI in severe cases were higher than those in non-severe cases(p<0.0001). However, sever cases and non-severe cases could not be discriminated clearly based on AI, because AI in both groups were widely distributed, overlapping with each other. [Conclusion][GLF]s on admission, which can be measured in about 3 hours by HPLC, is a valuable tool in predicting the severity of BASTA^<【○!R】> poisoning. (284 words)

急性口服除草剂BASTA^<[○！R]>在摄入6-40小时后会导致意识障碍、惊厥和呼吸暂停。因为在这些症状出现之前，患者看起来并不严重，所以对于严重患者的呼吸管理可能会迟到。另一方面，有时会为非严重患者进行不必要的强化治疗，例如血液净化。为了对这种中毒进行适当的管理，通过在严重症状出现之前正确估计这种中毒的严重程度，我们研究了血清草铵膦浓度（[GLF]s）和摄入量（AI）与患者严重程度的关系。[方法] 99例BASTA^<[○！R]>摄入进行了研究。51例病例至少出现以下3种体征之一：昏迷、全身性惊厥和呼吸暂停，定义为重度。48例未出现这些体征的病例被定义为非重度。在每种情况下，测量入院时的[GLF]s并估计AI。将[GLF]s与摄入后的小时数半对数相关。[结果]重症组的[GLF]s高于非重症组。在210 ppm（2小时）和15 ppm（8小时）连线上的所有病例均为重度。相反，在连接2小时80 ppm和8小时5 ppm的线下的所有情况均不严重。在这两条线之间，重度和非重度病例各占一半。重症组AI高于非重症组（P<0.0001）。然而，严重病例和非严重病例不能根据AI明确区分，因为两组AI分布广泛，相互重叠。[结论]采用HPLC法可在入院后3 h内检测出入院时的[GLF]s，对预测BASTA^<[○！中毒。(284字）

项目成果

Hirose Y, Kobayashi M, Koyama K, et al: "A Toxicokinetic Analysis in a Patient with Acute Glufosinate Poisoning"Hum. Exp. Toxicol.. 18. 305-308 (1999)

Hirose Y、Kobayashi M、Koyama K 等人：“急性草铵膦中毒患者的毒代动力学分析”Hum。

小山完二: "グルホネートを主成分とする除草剤による中毒" 日本病院薬剤師会雑誌. 35. 67-69 (1999)

Kanji Koyama：“基于草膦酸盐的除草剂中毒”日本医院药剂师协会杂志 35. 67-69 (1999)。

Koyama K: "The Poisoning Caused by an Herbicide Containing Glufosinate as a Main Component"Igakuno Ayumi. 185. 192-193 (1998)

小山K：“以草铵膦为主要成分的除草剂引起的中毒”伊学野步美。

Hirose Y,Kobayashi M,Koyama K et al: "A Toxicokinetic Analysis in a Patient with Acute Glufosinate Poisoning."Hum Exp Toxicol. 18. 305-308 (1999)

Hirose Y、Kobayashi M、Koyama K 等人：“急性草铵膦中毒患者的毒代动力学分析。”Hum Exp Toxicol。

Koyama K: "Glufosinate and a Surfactant: Which Component Produces Effects on the Central Nervous System in Acute Oral BASTA Poisoning?"Vet. Hum. Toxicol.. 41. 341-341 (1999)

Koyama K：“草铵膦和表面活性剂：哪种成分对急性口服 BASTA 中毒中枢神经系统产生影响？”兽医。