Estimation of re-stenosis after PTCA by laboratory test of coagulation and fibrinolysis.

为了通过凝血和纤溶分子标志物的实验室检测来检测PTCA后的烟道再狭窄，我们做了以下几个临床和实验医学项目。在临床上，我们证明再狭窄的比例依赖于器械，血管性血友病因子水平与该比例呈线性变化。在实验上，我们采用了一种新的改进的实验室试验方法，稀释组织因子凝血酶原时间（dil），研究了血液凝固系统，特别是自发性高血压（SHR）的高凝状态。PT)、凝血酶-抗凝血酶（TAT）值随血压和dil呈线性变化。pt .在小鼠系统中，我们通过实验室试验和血液凝固和纤维蛋白溶解系统的生化分析观察到蛇毒毒素2和LPS诱导的分解。血小板计数、TAT和纤维蛋白原随病死率和病理生理状态呈线性变化。此外，肾脏组织因子和PAI-1的mrna也随着实验室检查值和病理病理状态的变化而变化。

To detect flue re-stenosis after PTCA by laboratory tests of blood coagulation and fibrinolysis molecular markers, we made several clinical and experimental medical projects, as follows. Clinically, we demonstrated that the ratio of re-stenosis was dependent on the device and the levels of von Willebrand factor were linearly changed with the ratio. Experimentally, blood coagulation system, especially hypercoagulable state of spontaneously hypertensive (SHR) was studied by our newly modified laboratory test, diluted tissue factor prothrombin time (dil. PT), and thrombin-antithrombin (TAT) values were linearly changed with blood pressure and dil. PT.In the mice system, we observed a break down induced by verotoxin 2 and LPS by laboratory tests and biochemical analysis of blood coagulation and fibrinolysis system. Platelet count, TAT and fibrinogen was linearly changed with the fatal ratio and pathophysiological state. Moreover, m RNAs of tissue factor and PAI-1 in kidney were also changed with the values of laboratory tests and patholysiological state.