Estimation of re-stenosis after PTCA by laboratory test of coagulation and fibrinolysis.

为了通过凝血和纤溶分子标志物的实验室检测来检测PTCA术后再狭窄，我们进行了以下几个临床和实验医学项目。在临床上，我们证明了再狭窄的比率依赖于装置，并且von Willebrand因子水平与比率呈线性关系。实验方面，采用改良的凝血因子原时间(DIL)对自发性高血压(SHR)患者的凝血系统，特别是高凝状态进行了实验研究。PT)，凝血酶-抗凝血酶(TAT)值与血压和DIL呈线性关系。在小鼠系统中，通过实验室检查和凝血纤溶系统的生化分析，观察到维罗毒素2和脂多糖引起的破坏。血小板计数、TAT和纤维蛋白原与病死率和病理生理状态呈线性关系。此外，肾脏组织因子和PAI-1的mRNAs也随着实验室检查和病理生理状态的变化而变化。

To detect flue re-stenosis after PTCA by laboratory tests of blood coagulation and fibrinolysis molecular markers, we made several clinical and experimental medical projects, as follows. Clinically, we demonstrated that the ratio of re-stenosis was dependent on the device and the levels of von Willebrand factor were linearly changed with the ratio. Experimentally, blood coagulation system, especially hypercoagulable state of spontaneously hypertensive (SHR) was studied by our newly modified laboratory test, diluted tissue factor prothrombin time (dil. PT), and thrombin-antithrombin (TAT) values were linearly changed with blood pressure and dil. PT.In the mice system, we observed a break down induced by verotoxin 2 and LPS by laboratory tests and biochemical analysis of blood coagulation and fibrinolysis system. Platelet count, TAT and fibrinogen was linearly changed with the fatal ratio and pathophysiological state. Moreover, m RNAs of tissue factor and PAI-1 in kidney were also changed with the values of laboratory tests and patholysiological state.