Estimation of re-stenosis after PTCA by laboratory test of coagulation and fibrinolysis.

通过凝血和纤溶实验室测试评估 PTCA 后的再狭窄。

• 批准号: 10672191
• 负责人: KOMIYAMA Yutaka
• 金额: $ 1.79万
• 依托单位: Kansai Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10672191/
• 关键词: PTCA; re-stenosis; prothrombin time; von Willebrand factor; thrombin-antithrombin III; tissue factor; プロトロンビン時間; 自然発症高血圧ラット

To detect flue re-stenosis after PTCA by laboratory tests of blood coagulation and fibrinolysis molecular markers, we made several clinical and experimental medical projects, as follows. Clinically, we demonstrated that the ratio of re-stenosis was dependent on the device and the levels of von Willebrand factor were linearly changed with the ratio. Experimentally, blood coagulation system, especially hypercoagulable state of spontaneously hypertensive (SHR) was studied by our newly modified laboratory test, diluted tissue factor prothrombin time (dil. PT), and thrombin-antithrombin (TAT) values were linearly changed with blood pressure and dil. PT.In the mice system, we observed a break down induced by verotoxin 2 and LPS by laboratory tests and biochemical analysis of blood coagulation and fibrinolysis system. Platelet count, TAT and fibrinogen was linearly changed with the fatal ratio and pathophysiological state. Moreover, m RNAs of tissue factor and PAI-1 in kidney were also changed with the values of laboratory tests and patholysiological state.

为了通过凝血和纤溶分子标志物的实验室检测来检测经皮冠状动脉腔内成形术（PTCA）后气道再狭窄，我们进行了以下几个临床和实验医学项目。在临床上，我们证明了再狭窄的比率依赖于装置，并且von Willebrand因子的水平与比率呈线性变化。在实验上，采用我们新改良的组织因子凝血酶原时间（dil.）测定法，对自发性高血压（SHR）的凝血系统，尤其是高凝状态进行了研究。PT）、凝血酶-抗凝血酶（达特）值与血压、dil.在小鼠系统中，我们通过实验室检查和血液凝固和纤溶系统的生化分析观察到verotoxin 2和LPS诱导的破坏。血小板计数、达特和纤维蛋白原与病死率和病理生理状态呈线性关系。肾脏组织因子和派-1的mRNA也随实验室检查和病理变化而变化。

项目成果

Munakata M & Komiyama Y et al.: "Whole blood prothrombin time using diluted tissue factor is shortened in spontaneous hypertensive rats."Semin Thromb Hemost. 26. 97-100 (2000)

宗像中号

Sugatani J & Komiyama Y et al: "Activation of coagulation in C57BL/6 mice given verotoxin 2 (VT2) and the effect of co-administration of LPS with VT2."Thromb Res.. 100. 61-72 (2000)

菅谷 J

Yamamoto Y & Kamihata H et al.: "Factors associated with agiographic progression of moderate coronary artcry stenosis."Junkankika. 46(1). 78-83 (1999)

山本Y

山本克浩,神畠宏 他: "冠動脈造影所見により高度狭窄への進展を予測できるか."循環器科. 46. 78-83 (1999)

Katsuhiro Yamamoto、Hiroshi Kamabatake 等人：“可以通过冠状动脉造影结果预测严重狭窄的进展吗？”46. 78-83 (1999)

Sugatani J & Komiyama Y et al.: "Activation of coagulation in C57BL/6 mice given verotoxin 2 (VT2) and the effect of co-administration of LPS with VT2."Thromb Res. 100(1). 61-72 (2000)

菅谷 J