Vo_2 Kinetics during heavy exercise.

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In recent years, pulmonary oxygen uptake (Vo2) kinetics during exercise have been investigated intensely as a new criterion for the evaluation of aerobic work capacity, since a non-steady state is the more usual condition in organisms. From rigorous analysis of both steady- and non-steady state Vo2 responses to exercise, we are able to gain a deeper insight into the fundamental mechanisms of metabolic control and aerobic work capacity, which determine our adaptability to exercise in daily life. It is of critical importance to clarify both the precise features of the Vo2 response across the rest- exercise transition and whether 02 delivery and/or utilization is the rate-limiting factor in Vo2 response following the onset of exercise. We summarized recent studies on the above issues and, in particular, the results of investigations designed to alter (increase/decrease) oxygen delivery and/or utilization systematically and to determine the effect of such perturbations on the kinetic response of Vo2 to moderate exercise (where end-exercise Vo2 is below the lactate threshold (LT)) and heavy exercise (where it is above LT).