Translocator protein (TSPO)-induced ROS production by NADPH oxidases in neovascular age-related macular degeneration (C06)

点击翻译按钮获取中文摘要

Our hypothesis is that TSPO and NOX1-derived ROS are markers and effectors that trigger immune responses in neovascular retinal diseases. The overall goal of this project is to increase our understanding of how the TSPO/NOX axis drives retinal inflammatory diseases, such as AMD. To address this, we will identify and characterize in detail the signaling pathways regulating TSPO-induced ROS production by microglia in the laser-induced CNV model using transcriptomics and phosphoproteomics. In addition, we will identify the precise target cells of ROS produced by activated retinal microglia, decipher the molecular mechanisms underlying the detrimental effects of TSPO-induced ROS production on disease outcome and try to modulate that.