Study on the interaction between histamine and neuropeptide in the regulations of growth and food intake in ruminants

组胺与神经肽相互作用调节反刍动物生长和摄食的研究

• 批准号: 11660285
• 负责人: KUROSE Yohei
• 金额: $ 2.3万
• 依托单位: Kitasato University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11660285/
• 关键词: ruminant; histamine; glucagon-like peptide 1; growth hormone; food intake; brain; glucose; thioperamide; インスリン; チオペルアミド; 視床下部; バイオセンサー; 中枢神経系

1. Participations of histamine and glucose in the Inhibitory effect of glucagon-like peptide 1 (GLP-1) in the central regulation of food intakeThe inhibitory effect of GLP-1 on food intake was attenuated by a histamine H1 receptor antagonist, suggesting that GLP-1 would inhibit feeding behavior by activating histaminergic system in the brain. In addition, the change in histaminergic activity in the hypothalamus after GLP-1 administration was modulated by glucose availability in the neurons.2. Participations of GLP-1 and central histaminergic activity in the regulation of food intake in ruminantsSingle intracerebroventricular injection of a histamine H3-reoeptor antagonist, thioperamide, stimulated eating, however, continuous injection of GLP-1 into the hypothalamus did not change food intake in goats. GLP-1 failed to alter hypothalamic histamine levels. Therefore the participations of central histaminergic activity and GLP-1 in the suppression of eating were not confirmed in ruminants.3. Effects of central histaminergic activity on eating, GH secretion and glucose metabolism in ruminantsContinuous thioperamide administration into the brain stimulated GH secretion in sheep. The stimulatory effect of thioperamide was depressed after food supply. Blood glucose levels increased after the thioperamide administration. These results suggest that central histaminergio activity might stimulate GH secretion and gluooneogenesis in ruminants. The suppressive effect of central histaminergic activity on eating was confirmed in ruminants.

1.胰高血糖素样肽1（GLP-1）对摄食中枢调节的抑制作用中组胺和葡萄糖的调节作用GLP-1对摄食的抑制作用可被组胺H1受体拮抗剂减弱，提示GLP-1可能通过激活脑内组胺能系统而抑制摄食行为。此外，GLP-1给药后下丘脑中组胺能活性的变化受到神经元中葡萄糖可用性的调节。GLP-1和中枢组胺能活动在反刍动物摄食调节中的作用单次侧脑室注射组胺H3受体拮抗剂硫代哌丁胺可刺激山羊进食，但连续下丘脑注射GLP-1并不改变山羊的摄食。GLP-1未能改变下丘脑组胺水平。因此，中枢组胺能活性和GLP-1在反刍动物摄食抑制中的作用未得到证实.中枢组胺能活动对反刍动物摄食、生长激素分泌和糖代谢的影响脑内连续给予硫代哌丁胺刺激绵羊生长激素分泌。食物供应后，硫代哌丁胺的刺激作用被抑制。硫代哌丁胺给药后血糖水平升高。这些结果表明，中枢组胺神经活性可能刺激反刍动物GH分泌和糖蛋白生成。中枢组胺能活动对进食的抑制作用在反刍动物中得到证实。

项目成果

Kurose Y, Terashima Y: "Histamine reglulates food intake through modulating noradrenaline release in the para-ventricular nucleus"Brain Research. 828. 115-118 (1999)

Kurose Y、Terashima Y：“组胺通过调节室旁核中去甲肾上腺素的释放来调节食物摄入”大脑研究。

Kurose Y, Asakuma S, Sugino T, Terashima Y: "Central and peripheral effects of glucagon-like peptide 1 (GLP-1) on food intake and plasma concentrations of glucose and insulin in the goat"South African Journal of Animal Science. 29. 14-15 (1999)

Kurose Y、Asakuma S、Sugino T、Terashima Y：“胰高血糖素样肽 1 (GLP-1) 对山羊食物摄入以及葡萄糖和胰岛素血浆浓度的中枢和外周影响”《南非动物科学杂志》。

Kurose Y, Terashima Y: "Histamine regulates food intake through modulating noradrenaline release in the Para-ventricular nucleus"Brain Research. 828. 115-118 (1999)

Kurose Y，Terashima Y：“组胺通过调节室旁核中去甲肾上腺素的释放来调节食物摄入”大脑研究。

Kurose Y, Asakuma S, Sugino T, Terashima Y: "Central and peripheral effects of glucagon-like peptide 1 (GLP- 1) on food intake and plasma concentrations of glucose and insulin in the goat"South-African Journal of Animal Science. 29. 14-15 (1999)

Kurose Y、Asakuma S、Sugino T、Terashima Y：“胰高血糖素样肽 1 (GLP-1) 对山羊食物摄入以及葡萄糖和胰岛素血浆浓度的中枢和外周影响”《南非动物科学杂志》。

Terashima Y, Hamada Y, Satoh H, Kurose Y: "Noradrenaline secretary response cold d exposure in hypomagnesemic sheep fed a low Mg/high K Diet"South African Journal of Animal Science. 29. 205-206 (1999)

Terashima Y、Hamada Y、Satoh H、Kurose Y：“低镁血症羊饲喂低镁/高钾饮食时去甲肾上腺素秘书反应冷暴露”南非动物科学杂志。