课题基金 / 基金详情

Molecular analysis of mucosa associate lymphoid tissue lymphomas: a sudy of clonality and somatic mutations in immunoglobulin gene.

Molecular analysis of mucosa associate lymphoid tissue lymphomas: a sudy of clonality and somatic mutations in immunoglobulin gene.
粘膜相关淋巴组织淋巴瘤的分子分析:免疫球蛋白基因克隆性和体细胞突变的研究。
批准号:
11670180
负责人:
KON Shinichiro
金额:
$2.37万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
1999
资助国家:
日本
项目状态:
已结题
起止时间:
1999 至 2001

项目摘要

项目成果

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
Tissues from lymphoproliferative disorders arising in mucosa associated lymphoid tissue were analysed histopathologically, immunohistochemically and also by molecular techniques. Significant number of the cases were diagnosed as malignant lymphomas by demonstrating their monoclonality by Southern blot analysis using immunoglobulin gene probes. Biased usage of D segment of complementarity determining region 3 (CDR3) was obserbed in cases of ocular adnexal lymphoma, suggesting specific antigenic atimuli for generating malignant lymphomas in this region. Identification of VDJ construction was useful to know clonal expansion in separate regions and analysis of somatic mutations in variable region was also useful to recognize clonal development in multiple regions.
期刊论文(12)
专著(0)
科研奖励(0)
会议论文
Kon S.Kasai K, Tsuzuki N, Nishibe M, Kitagawa T, Nishibe T, Sato N.: "Lymphoepithelioma-like carcinoma of rectum : possible relation with EBV"Path.Res.Pract.. 197. 577-582 (2001)
Kon S.Kasai K、Tsuzuki N、Nishibe M、Kitakawa T、Nishibe T、Sato N.:“直肠淋巴上皮瘤样癌:与 EBV 的可能关系”Path.Res.Pract.. 197. 577-582 (2001)
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
Suzuki J.,Ohguto H.,Oguri N.,Satoh M.,Kon S.,Kogawa K.,Nakagawa T.: "Clinicopathological and immunogenetical analysis of mucosa assoiated lymphoid tissue lymphomas arsing in the conjunctiva."Jpn.J.Ophthalmol. 43. 155-161 (1999)
Suzuki J.、Ohguto H.、Oguri N.、Satoh M.、Kon S.、Kokawa K.、Nakakawa T.:“结膜粘膜相关淋巴组织淋巴瘤的临床病理学和免疫遗传学分析。”Jpn.J.O善眼科
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
Tomaru U, Ishikura H, Kon S, Kanda M. Harada H, Yoshiki T.: "Primary lymphoma of the prostate with features of low grade B-cell lymphoma of mucosa associated lymphoid tissue : A rare cause of urinary obstruction"J.Urol.. 162. 496-497 (1999)
Tomaru U、Ishikura H、Kon S、Kanda M. Harada H、Yoshiki T.:“以粘膜相关淋巴组织低度 B 细胞淋巴瘤为特征的前列腺原发性淋巴瘤:尿路梗阻的罕见原因”J.Urol
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
Kon S., Kasai K., Tsuzuki N., Nishibe M., Kitagawa T., Sato N.: "Lymphoepithelioma-like carcfnoma of rectum: possible relation with EBV"Path. Res. Pract.. 197. 577-582 (2001)
Kon S.、Kasai K.、Tsuzuki N.、Nishibe M.、Kitakawa T.、Sato N.:“直肠淋巴上皮瘤样癌:与 EBV 的可能关系”路径。
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
11
    海外基金