Association between antlhypertensive effect and glucose intolerance with mild exercise therapy in patients with essential hypertension.

原发性高血压患者轻度运动疗法的抗高血压效果与葡萄糖耐受不良之间的关联。

• 批准号: 11670397
• 负责人: TSUCHIYA Yoshihiro
• 金额: $ 2.3万
• 依托单位: Fukuoka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11670397/
• 关键词: Exercise training; essential hypertension; glucose metabolism; insulin sensitivity; cardiovascular disease

The main purpose of the present study was to examine degree of dependency for abnormal glucose metabolism of hypertensive patients on insulin-dependent or -independent glucose uptake, which was determined by an intravenous glucose tolerance test (IVGTT) before and after a 10-week mild exercise training (corresponding approximately 50% of maximum oxygen uptake). Simultaneously, other factors including body mass index, waist-hip ratio, %fat and I biochemical parameters such as total, LDL and HDL cholesterol, triglyceride were determined. After a 10-week exercise training, both insulin-dependent and -independent glucose uptakes were significantly improved and this was accompanied with an improvement of insulin secretion. There was a decrease tendency in waist-hip ratio, %fat, LDL i cholesterol and triglyceride, but no change in body mass index, total cholesterol and free fatty acid. In addition, there was no particular correlation between the improvement of insulin-dependent or -independent glucose uptake and the changes of examined biochemical and physiological factors. This was probably due to relatively small number of patient group. Association study between gene polymorphisms of ACE, angiotensinogen and ATI receptor and the degree of improvement of glucose uptake is currently on going. These results will be reported all together.

本研究的主要目的是检查高血压患者糖代谢异常对胰岛素依赖性或非依赖性葡萄糖摄取的依赖程度，这是通过静脉葡萄糖耐量试验（IVGTT）确定之前和之后的10周轻度运动训练（相当于约50%的最大摄氧量）。同时测定体重指数、腰臀比、%脂肪、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯等生化指标。经过10周的运动训练后，胰岛素依赖性和非依赖性葡萄糖摄取均显著改善，这伴随着胰岛素分泌的改善。腰臀比、%脂肪、LDL-i胆固醇和甘油三酯呈下降趋势，而体重指数、总胆固醇和游离脂肪酸无变化。此外，胰岛素依赖性或非依赖性葡萄糖摄取的改善与检查的生化和生理因素的变化之间没有特别的相关性。这可能是由于患者组数量相对较少。ACE、血管紧张素原和ATI受体基因多态性与葡萄糖摄取改善程度的相关性研究正在进行中。这些结果将一并报告。

项目成果

Sakamoto, et al.: "Influence of mild exercise at the lactate threshold on glucose effecti ve ness"J Appl Physiol. 87. 2305-2310 (1999)

Sakamoto 等人：“乳酸阈值下的轻度运动对葡萄糖有效性的影响”J Appl Physiol。

Fujitani et al.: "Intravenous glucose tolerance test-derived glucose effectiveness in strength-trained humans"Metabolism. 47. 874-877 (1998)

Fujitani 等人：“静脉葡萄糖耐量试验衍生的力量训练人类的葡萄糖有效性”代谢。

Shono et al.: "Effects of low intensity aerobic training on skeltal muscle capillary and blood lipoprotein profiles"J Atheroscler Thromb. 9. 78-85 (2002)

Shono 等人：“低强度有氧训练对骨骼肌毛细血管和血液脂蛋白谱的影响”J Atheroscler Thromb。

Shono, et al.: "Effects of low intensity aerobic training on skeltal muscle capillary and blood lipoprotein profiles"J Atheroscler Thromb. 9. 78-85 (2002)

Shono 等人：“低强度有氧训练对骨骼肌毛细血管和血液脂蛋白谱的影响”J Atheroscler Thromb。

Sakamoto et al.: "Influence of mild exercise at the lactate threshold on glucose effectiveness"J Appl Physiol. 87. 2305-2310 (1999)

Sakamoto 等人：“乳酸阈值下的轻度运动对葡萄糖有效性的影响”J Appl Physiol。