Association between antlhypertensive effect and glucose intolerance with mild exercise therapy in patients with essential hypertension.

本研究的主要目的是检查高血压患者糖代谢异常对胰岛素依赖性或非依赖性葡萄糖摄取的依赖程度，这是通过静脉葡萄糖耐量试验（IVGTT）确定之前和之后的10周轻度运动训练（相当于约50%的最大摄氧量）。同时测定体重指数、腰臀比、%脂肪、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯等生化指标。经过10周的运动训练后，胰岛素依赖性和非依赖性葡萄糖摄取均显著改善，这伴随着胰岛素分泌的改善。腰臀比、%脂肪、LDL-i胆固醇和甘油三酯呈下降趋势，而体重指数、总胆固醇和游离脂肪酸无变化。此外，胰岛素依赖性或非依赖性葡萄糖摄取的改善与检查的生化和生理因素的变化之间没有特别的相关性。这可能是由于患者组数量相对较少。ACE、血管紧张素原和ATI受体基因多态性与葡萄糖摄取改善程度的相关性研究正在进行中。这些结果将一并报告。

The main purpose of the present study was to examine degree of dependency for abnormal glucose metabolism of hypertensive patients on insulin-dependent or -independent glucose uptake, which was determined by an intravenous glucose tolerance test (IVGTT) before and after a 10-week mild exercise training (corresponding approximately 50% of maximum oxygen uptake). Simultaneously, other factors including body mass index, waist-hip ratio, %fat and I biochemical parameters such as total, LDL and HDL cholesterol, triglyceride were determined. After a 10-week exercise training, both insulin-dependent and -independent glucose uptakes were significantly improved and this was accompanied with an improvement of insulin secretion. There was a decrease tendency in waist-hip ratio, %fat, LDL i cholesterol and triglyceride, but no change in body mass index, total cholesterol and free fatty acid. In addition, there was no particular correlation between the improvement of insulin-dependent or -independent glucose uptake and the changes of examined biochemical and physiological factors. This was probably due to relatively small number of patient group. Association study between gene polymorphisms of ACE, angiotensinogen and ATI receptor and the degree of improvement of glucose uptake is currently on going. These results will be reported all together.