Imaging Diagnosis of Prostate Concer using Magnetization Tronsfer Effect

利用磁化转移效应对前列腺癌的影像诊断

• 批准号: 11670880
• 负责人: KOBAYASHI Shigeki
• 金额: $ 0.7万
• 依托单位: Mie University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11670880/
• 关键词: Magnetization Transfer Contrast; Prostate Concer; MRI; Cross Relaxation; Imaging Diognosis; MTC

PURPOSE : To assess the feasibility of magnetization transfer(MT)MR imaging in predicting the rocalization of prostate cancer and in monitoring the effectiveness of hormonal therapy for prostate cancer. MATERIALS AND METHODS : Three-dimensional SPGR MR imaging examinations with additional MT pules were performed in 36 patients(21 of no nco-adjuvant therapy group, 15 of neo-adjuvant hormonal therapy group)with biopsy-proved prostate cancer. MT pulses were irradiated to the three points of off-set frequency, 300Hz, 1200Hz and 2000Hz. Magnetization transfer ratio images(MTR images)were calculated with obtained data in all patients using analytical software (MRVISION). MTRs of cancer lesions, normal outer zone and benign prostatic hyperplasia(BPH)were measured. MTRs of no neo-adjuvant therapy group were compared with those of nco-adjuvant hormonal therapy group. Six patients underwent radical prostatectomy(3 of no nco-adjuvant group, 3 of neo-adjuvant therapy group)and MTR images were comp … More ared with pathological findings of cancer localization. The Correlation between serum prostate-specific antigen(PSA)levels and MTRs of cancer lesions were evaluated. RESULTS : Statistical significance difference was found between MTRs of normal outer zone and those of cancer lesions and between those of normal outer zone and those of BPH on MT1200 and MT2000 images. No statistical difference was found between MTRs of cancer lesions and those of BPH.NO significant correlation was found between PSA levels and MTRs of cancer lesions. In three patients who underwent radical prostatectomy in no neo-adjuvant therapy group, cancer lesions were well demonstrated on MTR images with good correlation to pathological findings. However, feasibility of MTR images was poor in three patients who underwent radical prostatectomy in nco-adjuvant therapy group. CONCLUSION : MTR image was useful to assess cancer localization in prostate outer zone and enables the evaluation for presence of prostate cancer when post biopsy hinder interpretation with ordinary MR imaging alone. Less

目的：探讨磁转移（MT）磁共振成像在预测前列腺癌局部化和监测前列腺癌激素治疗效果方面的可行性。材料与方法：对36例活检证实的前列腺癌患者（非辅助治疗组21例，新辅助激素治疗组15例）进行三维SPGR磁共振成像检查并附加MT脉冲。MT脉冲分别照射到偏移频率300Hz、1200Hz和2000Hz三个点。利用MRVISION分析软件计算所有患者的磁化传递比图像（MTR图像）。测量癌灶、正常外区及良性前列腺增生（BPH）的MTRs。比较无新辅助治疗组与非辅助激素治疗组的mtr。对6例根治性前列腺切除术患者（无辅助治疗组3例，新辅助治疗组3例）的MTR图像进行比较。评估血清前列腺特异性抗原（PSA）水平与癌灶MTRs的相关性。结果：MT1200和MT2000影像上正常外区与癌灶、正常外区与BPH的mri差异均有统计学意义。肿瘤病变的MTRs与前列腺增生的MTRs无统计学差异。PSA水平与癌灶MTRs无显著相关性。无新辅助治疗组行根治性前列腺切除术的3例患者，MTR图像显示癌灶清晰，与病理表现有良好的相关性。然而，非辅助治疗组3例根治性前列腺切除术患者MTR图像的可行性较差。结论：MTR图像有助于评估前列腺外区癌的定位，当活检后仅用普通MR成像进行解释时，可以评估前列腺癌的存在。少