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The association study of the polymorphism of the receptors and response to antipsychotic drugs in schizophrenia

精神分裂症受体多态性与抗精神病药物反应的关联研究

基本信息

批准号：
11670968
负责人：
NAKAMURA Michiko
金额：
$ 1.92万
依托单位：
Toho Unversity
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2001
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11670968/
关键词：
schizophrenia heterogeneity the 5HTR2A gene T102C polymorphism nongenetic causes juvenile-onset adult-onset schizophrenia hSKCa3 gene ハロペリドール治療反応性 DRD4遺伝子 hSKCa3 CAG repeat 多型レセプター遺伝子多型性 global assessment scale

项目摘要

The etiological heterogeneity is considered to exist from the genetic study of schizophrenia. We should study the etiology, being acknowledgeed with the heterogeneity. Recently the relationship of negative symptoms of schizophrenia and the serotonerglc receptor blockade receive much attention. We studied about the position 102 polymorphism by Msp I restriction enzyme in the exon 1 of the 5HTR2A gene. There are Cl, C2 polymorphism at T102C polymorphism. There were no significant differences between the L(+) group (the group of patients with the familial loading) and healthy control group.In the general population there are likely to be several causal or susceptibility genes and nongenetic causes. We studied of the group of schizophrenic patients of juvenile-onset and also the ones of adult-onset schizophrenia on the following four factors. (1) the obstetrical complications of the mothers of the patients. (2) the existence of genetic loading (3) the existence of the stresses of the obvio … More us familial ones until adulthood. (4) existence of the obvious stresses in the school life 〔Results〕(1) The obstetrical complications were significantly more Inthe juvenile schizophrenia than schizophrenia in the adulthood. (2) There were no significant differences on the existence of genetic loading between juvenile and adult onset schizophrenia. (3) There were obviously more stresses until the adulthood in the group of juvenile schizophrenia than in adult-onset schizophrenia (statistically significant at 5 % level). (4) The obvious stresses in their school lives by the high school ages were more significantly in the group of juvenile schizophrenia. There were more patients who have none of these factors inthe adult onset than juvenile onset schizophrenia. There were more patients who have three factors in the juvenile onset schizophrenia than adult-onset schizophrenia.We sometimes recognize the anticipation in the families of schizophrenia. We detected the polymorphism of hSKCa3 (human small condactance calsium- activated potassium channel) in the schizophrenia. The CAG repeat polymorphism were detected.The association studies between the receptor gene polymorphism and response to antipsychotlcs were to be done. But yet we could not collect the enough samples. We surely intend to finish these association studies. Less

精神分裂症的遗传学研究认为存在病因异质性。应重视病因学的研究，认识其异质性。近年来，精神分裂症阴性症状与多巴胺能受体阻滞剂的关系备受关注。本研究应用限制性内切酶Msp Ⅰ对5HTR2A基因外显子1第102位多态性进行了研究。T102C多态性存在Cl、C2多态性。L（+）组（有家族负荷的患者组）与健康对照组之间无显著性差异，在一般人群中可能存在多个致病或易感基因和非遗传原因。本研究对青少年型和成年型精神分裂症患者进行了以下四个因素的研究。(1)患者母亲的产科并发症。(2)遗传负荷的存在（3）明显的应力的存在， ...更多信息我们家族的人直到成年。(4)（1）青少年期精神分裂症的产科并发症明显多于成年期精神分裂症。(2)青少年与成人首发精神分裂症的遗传负荷存在差异无统计学意义。(3)青少年精神分裂症组至成年期的应激反应明显多于成年期精神分裂症组（5%水平，有统计学意义）。(4)青少年精神分裂症组在高中阶段学校生活压力明显。在成人型精神分裂症患者中，无上述因素者多于青少年型精神分裂症。青少年型精神分裂症患者中同时具有三个因子的人数多于成年型精神分裂症患者。检测了人类小电导钙激活钾通道（hSKCa 3）在精神分裂症患者中的多态性。检测CAG重复序列多态性，并进行受体基因多态性与抗精神病药物疗效的相关性研究。但我们无法收集到足够的样本。我们当然打算完成这些关联研究。少