The association study of the polymorphism of the receptors and response to antipsychotic drugs in schizophrenia

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The etiological heterogeneity is considered to exist from the genetic study of schizophrenia. We should study the etiology, being acknowledgeed with the heterogeneity. Recently the relationship of negative symptoms of schizophrenia and the serotonerglc receptor blockade receive much attention. We studied about the position 102 polymorphism by Msp I restriction enzyme in the exon 1 of the 5HTR2A gene. There are Cl, C2 polymorphism at T102C polymorphism. There were no significant differences between the L(+) group (the group of patients with the familial loading) and healthy control group.In the general population there are likely to be several causal or susceptibility genes and nongenetic causes. We studied of the group of schizophrenic patients of juvenile-onset and also the ones of adult-onset schizophrenia on the following four factors. (1) the obstetrical complications of the mothers of the patients. (2) the existence of genetic loading (3) the existence of the stresses of the obvio … More us familial ones until adulthood. (4) existence of the obvious stresses in the school life 〔Results〕(1) The obstetrical complications were significantly more Inthe juvenile schizophrenia than schizophrenia in the adulthood. (2) There were no significant differences on the existence of genetic loading between juvenile and adult onset schizophrenia. (3) There were obviously more stresses until the adulthood in the group of juvenile schizophrenia than in adult-onset schizophrenia (statistically significant at 5 % level). (4) The obvious stresses in their school lives by the high school ages were more significantly in the group of juvenile schizophrenia. There were more patients who have none of these factors inthe adult onset than juvenile onset schizophrenia. There were more patients who have three factors in the juvenile onset schizophrenia than adult-onset schizophrenia.We sometimes recognize the anticipation in the families of schizophrenia. We detected the polymorphism of hSKCa3 (human small condactance calsium- activated potassium channel) in the schizophrenia. The CAG repeat polymorphism were detected.The association studies between the receptor gene polymorphism and response to antipsychotlcs were to be done. But yet we could not collect the enough samples. We surely intend to finish these association studies. Less