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Clinical Research on Psychiatric Problems of Cutting-Edge Medicine :

尖端医学精神问题的临床研究：

基本信息

批准号：
11670973
负责人：
FUKUNISHI Isao
金额：
$ 1.09万
依托单位：
Tokyo Metropolitan Organization of Medical Research
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2001
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11670973/
关键词：
Psychiarty Cutting-Edge Medicine Organ Transplantation Liaison Consultation リエゾン精神医学うつ HIV がん

项目摘要

We performed clinical research on psychiatric problems of cutting-edge medicine for three years from 1999 to 2001.The subjects were patients who receive cutting-edge medicine such as a pair of the recipient who underwent organ transplantation and their living donor. Moreover, we used donors' families as the subjects. We also use patients with end-stage renal failure on dialysis therapy as the subjects.We performed psychiatric interviews for the subjects. The psychiatric diagnosis was done using the DSM-IV psychiatric criteria. In addition, we administered various psychological questionnaires in order to assess their psychological aspects and QOL aspects.The results were as follows. The prevalence rate of psychiatric disorders was more than 50% in adult recipients within three months following living donor liver transplantation. The main psychiatric disorders were delirium and major depression. The delirium means postoperative delirium. Major depression was manifested in a paradoxical form which refers to depressive symptoms in spite of favorable outcome after transplantation. As for psychopathological aspects, the paradoxical depression was closely related to the existence of guilt feelings in the recipients' mind. On the contrary, the prevalence rates of psychiatric disorders were very low in the donors and child recipients. The same results were obtained in kidney transplantation. However, the prevalence rate was lower for living donor Kidney transplantation than for living donor liver transplantation. As the duration after transplantation was longer, the prevalence rate of psychiatric disorders was lower. However, we have to examine their psychiatric and psychological conditions since the period of our investigation was only for three years.

从1999年到2001年，我们进行了三年的前沿医学精神病学问题的临床研究。研究对象是接受尖端医学治疗的患者，比如一对接受器官移植的患者和他们的活体捐赠者。此外，我们以献血者家属为研究对象。我们也使用透析治疗的终末期肾功能衰竭患者作为研究对象。我们对研究对象进行了精神病学访谈。精神病学诊断采用DSM-IV精神病学标准。此外，我们进行了各种心理问卷调查，以评估他们的心理方面和生活质量方面。结果如下：活体肝移植术后3个月内成人受者精神障碍患病率超过50%。主要精神障碍为谵妄和重度抑郁症。谵妄是指术后谵妄。重度抑郁症以一种矛盾的形式表现出来，即尽管移植后预后良好，但仍出现抑郁症状。在心理病理方面，悖论性抑郁与接受者心中内疚感的存在密切相关。相反，精神疾病的患病率在捐赠者和儿童接受者中非常低。在肾移植中也得到了同样的结果。然而，活体肾移植的患病率低于活体肝移植。随着移植时间的延长，精神障碍的患病率降低。但是，调查时间只有3年，因此必须对他们的精神和心理状况进行调查。”