Effect of endothelin receptor antagonist on the liver graft

肝细胞癌(简称肝细胞癌)切除后预后有所改善。这项研究是为了确定影响无病生存时间的独立危险因素。用Knoell等人提出的组织学活动指数(HAI)评分对肝炎活动度进行分级。比例风险分析显示了以下结果。影响患者长期无复发生存的独立因素为年龄、吲哚青绿滞留率、肿瘤结节数、肿瘤包膜侵犯及门脉侵犯情况、HAI评分评价炎症活动。多变量分析证实，除了年龄、肝脏储备和肿瘤特征外，炎症活动的重要性也是复发的危险因素。要实现更长的无病生存，不仅要及早发现，而且要抑制并存的肝炎。

The prognosis hepatocellular carcinoma (HCC) has been improved after hepatic resection. This study was undertaken to determine independent risk factors affecting the length of disease-free survival. Activity of hepatitis was graded by the histological activity index (HAI) score, which was proposed by Knodell et al. Proportional hazard analysis demonstrated thefollowing results. The independent factors for long-term survival without recurrence were the patients' age, indocyanine green retention rate, number of tumor nodules, microscopic tumor capsular invasion and portal infiltration, and inflammatory activity assessed by HAI score. The importance of inflammatory activity in addition to aging, hepatic reserve and tumorcharacteristics was confirmed as a risk factor for recurrence by multivariate analysis. To achieve longer disease-free survival, not only early detection but also suppression of co-existing hepatitis is prerequisite.