Approach for the establishment of new way of brain resuscutation

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Brain ischemia leads to severe damage in the form of delayed neuronal cell death. We have been investigated the mechanisms of delayed neuronal cell death in terms of the mechanisms of immunosuppressant, such as cyclosporin A (CsA) and FK506. We show here the drastic neuroprotection of the CsA in the forebrain ischemia is not only due to inhibition of calcineurininduced cell death through dephosphorylation of proapoptotic protein Bad, but also due to protection of mitochonorial damage which is caused by the MPT (Mitochondrial Permeability Transition) pore formation through cyclophilin D (CyPD), one of the prolyl cis/trans isomerase family members.These results shed light on the clinical application and development of new drugs for the treatment of ischemic damage in the brain as well as in the heart and liver.