The influence of endocrine disrupting substances on the disorder of male external genitalia

内分泌干​​扰物对男性外生殖器疾病的影响

• 批准号: 11671570
• 负责人: HAYASHI Yutaro
• 金额: $ 2.18万
• 依托单位: Nagoya City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11671570/
• 关键词: hypospadias; endocrine disrupting substance; dioxin; 外因性内分泌攪乱物質; 性分化異常

We encounter environmental problems, especially endocrine disrupting substances which affects living things on earth. These substances have been described to induce disorders about sex differentiation. Male alligators tended to have tiny penis with deformity because of endocrine disrupting substances in the US.In Japan dioxin has been one of the most famous endocrine disrupting substances which is produced at incinerators. It was reported that the incidence of hypospadias was increasing which is caused by somewhat endocrine problems in fetus. We investigated five women and examined the dioxin level in blood whose boys suffered from penile disorder called hypospadias. All of their boys were under five and five years old. There was no significant difference between general controls and the motehrs as for the dioxin level in blood.

我们遇到了环境问题，特别是影响地球上生物的内分泌干扰物质。这些物质被描述为引起性别分化的障碍。在美国，由于内分泌干扰物质，雄性扬子鳄的阴茎往往很小，并出现畸形。在日本，二恶英是最著名的内分泌干扰物质之一，它是由焚烧炉产生的。有报道称，由于胎儿某些内分泌问题引起的尿道下裂的发生率呈上升趋势。我们调查了五名女性，并检测了血液中的二恶英水平，这些女性的男孩患有称为尿道下裂的阴茎疾病。他们所有的男孩都不到五岁到五岁。血中二恶英水平，一般对照组与正常对照组无显著差异。

项目成果

Yutaro Hayashi et al: "One-stage repair of moderately severe hypospadias using a transverse preputial tubularized island flap"International Journal of Urology. 8. 165-170 (2001)

Yutaro Hayashi 等人：“使用横向包皮管状岛状皮瓣一期修复中重度尿道下裂”国际泌尿外科杂志。

Yutaro Hayashi et al: "The modified Koyanagi repair for severe proximal hypospadias"BJU International. 87. 235-238 (2001)

Yutaro Hayashi 等人：“改良小柳修复术治疗严重近端尿道下裂”BJU International。