A role of ovarian steroid receptors and cell-cell inter action at the feto-maternal interface in differentiation into decidual cells

胎盘的发育和蜕膜化过程明显受到植入后胎儿-材料界面处免疫系统的细胞和产物的影响。子宫内膜成分的生长和分化的地形和时间差异表明，局部自分泌和旁分泌因素调节性类固醇的作用。在以前的研究中，我们证明了建立一个永久的子宫内膜间质成纤维细胞系和滋养层细胞系。在这里，我们研究了蜕膜化机制和细胞间的相互作用，在胎儿材料界面，使用这些细胞系。

Development of the placenta and decidualizing process is clearly influenced by cells and products of the immune system at the feto-material interface after implantation. Topograplucal and temporal differences in both the growth and differentiation of endometrial elements suggest that local autocrine and paracrine factors modulate the effects of sex steroids. In a previous study, we demonstrated to establish a permanent endometrial stromal fibroblast cell line and a trophoblast cell line. Here we have investigated decidualizing mechanisms and cell-cell interactions at the feto-material interface, using these cell lines.