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The epithelial damages of nasal mucosa in nasal allergy

鼻过敏时鼻黏膜上皮的损伤

基本信息

批准号：
11671699
负责人：
WATANABE Kensuke
金额：
$ 2.11万
依托单位：
Dokkyo University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2001
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11671699/
关键词：
eosinophil lysis degranulation nasal mucosa epithelial damage ECP in nasal mucus ECP in serum electron microscope 好酸球血漿ECP 鼻アレルギー ECP 好酸球の脱顆粒好酸球壊死好酸球顆粒蛋白

项目摘要

1) The granule proteins of eosinophils were initially induced in the cytoplasm via finetubles and then diffused in the extracellular space through micro-destruction of the plasma membrane. When the eosinophil lysis was advanced, a large amount of granule contents was released into the extracellular space.2) The epithelial damage, which was conspicuous intercellular edema or epithelial shedding, was found to be remarkable in the anterior nasal mucosae, but minor in the posterior nasal mucosae. The total number of the eosinophils which migrated to epithelial region was not significantly different between in the damaged epithelium and in the intact one. But the rate of cytolytic eosinophils was significantly higher in the area of severely shedded epithelium than in the area of intact epithelium.3) The epithelial damage which was conspicuous intercellular edema or epithelial shedding was found to be remarkable in the anterior nasal mucosae, but minor in the posterior nasal mucosae. The total number of the eosinophils which migrated to epithelial region was not significantly different between in the damaged epithelium and in the intact one. But the rate of cytolytic eosinophils was significantly higher in the area of severely shedded epithelium than in the area of intact epithelium.4) ECP in serum was released from destroyed eosinophils in test tube after the blood collection and it indicated the easiness of eosinophil destruction.

1)嗜酸性粒细胞的颗粒蛋白最初通过微管在细胞质中被诱导，然后通过质膜的微破坏扩散到细胞外空间。随着嗜酸性粒细胞溶解程度的加深，大量颗粒物质释放到细胞外。2）鼻前粘膜上皮细胞损伤明显，表现为细胞间水肿或上皮脱落，鼻后粘膜上皮细胞损伤较轻。上皮损伤组和正常组迁移到上皮区的嗜酸性粒细胞总数无显著性差异。但上皮脱落严重的部位嗜酸性粒细胞的比例明显高于上皮完整的部位。3）前鼻粘膜上皮损伤明显，表现为明显的细胞间水肿或上皮脱落，后鼻粘膜上皮损伤较轻。上皮损伤组和正常组迁移到上皮区的嗜酸性粒细胞总数无显著性差异。但上皮脱落严重区的嗜酸性粒细胞溶解率明显高于上皮完整区。4）采血后，血清中嗜酸性粒细胞被破坏后释放出ECP，表明嗜酸性粒细胞易被破坏。