Affinity and crystallochemical properties of amorphous calcium phosphate-collagen complex
无定形磷酸钙-胶原蛋白复合物的亲和力和晶体化学性质
基本信息
- 批准号:11671817
- 负责人:
- 金额:$ 2.11万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:1999
- 资助国家:日本
- 起止时间:1999 至 2001
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
There is different physical chemistry-character between crystalline and amorphous substance. This study aimed at developing a high amorphous calcium phosphate-collagen complex material of living body affinity using this character. It was suggested that the collagen type I which has calcification ability from a precedence experiment differs from the collagen type I which is not calcified in points, such as bridge construction. Therefore, development of the bridge construction analyzing method of collagen was also united and tried. A part of the result was released as "heat analytic research of softening dentine", "examination about the influence which demineralization processing does to the quality of dentine organic, especially collagen", and "research of a collagen type I heat decomposition process." Moreover, we pursued about the crystalline high enamel apatite most as part [ the characteristic of a living body apatite ] of research, and decided to aim at evaluation of living body co … More nformity, such as apatite joint ability, based on the knowledge. Therefore, "method by the size of an enamel crystal and the integration width of the presumed-X-rays diffraction peak [ lattice ] of disorder -", "presumption of the carbonic acid ion distribution ratio under apatite crystal by a man's enamel specific gravity part drawing and a content water ratio", "examination of disorder of the size of an enamel crystal and a *attice by the integration width of an X ray diffraction peak", etc. were studied. In order to measure the influence of an in plant to a living body, the cell culture experiment and the animal experiment were conducted. Those results "Potential application of micro-CT for study of bone-Ti implant interface", "Application of high resolution micro focus X-ray CT for the observation of human tooth", It announced as "Histo-pathological study of bone formation using porous hydroxyapatite-BMP composite in dog jaw bone defect." The amorphous usefulness as a biomechanical material was suggested from these results. In the future, establishment and the applied research of the manufacturing technique of this composite material are pointed out as a subject. Less
晶态物质和非晶态物质具有不同的物理化学性质。本研究旨在利用这一特性开发一种具有活体亲和力的高无定形磷酸钙-胶原复合材料。从优先实验中发现,具有钙化能力的I型胶原不同于未钙化的I型胶原,如桥梁建设。为此,对胶原蛋白桥梁结构分析方法的发展也进行了统一和尝试。部分成果发布为《软化牙本质的热分析研究》、《脱矿处理对牙本质有机,尤其是胶原质质量影响的考察》、《I型胶原热分解工艺研究》。此外,我们把结晶高釉质磷灰石作为研究的一部分,并决定以评价活体co…为目标。更多的畸形,如磷灰石的关节能力,基础知识。为此,对“用釉质晶体大小和推测的无序X射线衍射峰[晶格]积分宽度的方法”、“用人的釉质比重部分图和含水率推测磷灰石晶体下碳酸离子分布比”、“用X射线衍射峰积分宽度检验釉质晶体和晶格的无序大小”等进行了研究。为了测量植物体内AN对活体的影响,进行了细胞培养实验和动物实验。这两项研究成果分别是《微型CT在骨-钛种植体界面研究中的潜在应用》、《高分辨率微焦点X射线CT在人牙组织学观察中的应用》、《多孔羟基磷灰石-骨形态发生蛋白复合体在犬颌骨缺损区成骨的组织病理学研究》。从这些结果可以看出无定形材料作为生物力学材料的用途。指出了今后该复合材料制造技术的建立和应用研究方向。较少
项目成果
期刊论文数量(64)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Y Akimoto et al.: "A long submandibular sialolith lying in the Wharton's duct"Oral and Maxillofical Radiology Today. 615-617 (2000)
Y Akimoto 等人:“位于沃顿管中的长颌下唾液石”《今日口腔颌面放射学》。
- DOI:
- 发表时间:
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- 影响因子:0
- 作者:
- 通讯作者:
寒河江登志朗: "エナメル質結晶の大きさと格子の乱れの推定"エナメル質懇話会雑誌. 7. 69-70 (2000)
Toshiro Sagae:“牙釉质晶体尺寸和晶格紊乱的估计”牙釉质学会杂志 7. 69-70 (2000)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
SAKAE, T: "Application of micro-CT for study of bone-Ti implant interface and its future posibility"J. Hard Tissue Biol.. 9(1)(in press). (2000)
SAKAE,T:“微型 CT 在骨-钛种植体界面研究中的应用及其未来的可能性”J。
- DOI:
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- 影响因子:0
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田川 元: "軟化象牙質の熱分析的研究"日大口腔科学. 27. 297-303 (2001)
田川元:“软化牙本质的热分析研究”日本大学口腔学院27. 297-303(2001)。
- DOI:
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- 影响因子:0
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寒河江登志朗: "歯のできかたのしくみ その分子生物学的展望(21世紀への歯の形態形成・再生研究の指針)"Journal of Hard Tissue Biology. 8. (1999)
Toshiro Sagae:“牙齿形成机制及其分子生物学视角(21世纪牙齿形态发生和再生研究指南)”硬组织生物学杂志8。(1999)。
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SAKAE Toshiro其他文献
SAKAE Toshiro的其他文献
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{{ truncateString('SAKAE Toshiro', 18)}}的其他基金
Free electron laser ablation effects and its application for dental enamel and dentin
自由电子激光烧蚀牙釉质和牙本质的效果及其应用
- 批准号:
17591927 - 财政年份:2005
- 资助金额:
$ 2.11万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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