Application of plasma proteins as blood substitutes

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Nishi et al. found the inhibitory effects of pyridoxalated hemoglobin polyoxyethylene conjugate (PHP) on the intestinal peristaltic movement, the facilitatory effect of α_1-acid glycoprotein (α_1-AGP) on the passage of red blood cells through filters with micropores, and the vasodilator action of α_1-AGP in aorta.Maeda et al. found that S-nitrosylation of α_1-protease inhibitor (α_1-PI) occurring under physiological conditions should diverse in the biological functions contributing to cytoprotective effects of α_1-PI, and suggested that S-nitrosylated α_1-AGP would have the multiple biological functions.Otagiri et al. purified recombinant human serum albumin (rHSA), secreted by a Pichia pastoris expression system, and showed very similar structural characteristics, stability and ligand-binding properties of the rHSA as HSA isolated from sera.Uno et al. analyzed the amino acid residues surrounding the cofactor in the structures of a four-helix bundle heme protein, cytochrome b562 from E. coli, and developed a strategy for designing an exogenous ligand binding pocket into this protein.