How Spinal Afferent Neurons Control Appetite and Thirst

该项目旨在为肠道如何与大脑沟通、如何调节摄入的食物和液体量提供重要的新见解。该提案希望产生关于肠-脑交流的新知识，以及来自肠道的主要感觉神经之一如何传递有关口渴和食欲的信息。该项目解决了一些基本问题，这些问题依赖于我们实验室最近才开发出来的技术。我们希望证明一条主要的新感觉神经通路，从肠道到大脑，在食欲和口渴的感觉中起着重要作用。我们将学习当人们吃东西和喝饮料时，肠道与大脑的沟通是如何形成“饱腹感”的。

This project aims to provide major new insights about how the gut communicates with the brain, to regulate how much food and fluids have been consumed. The proposal expects to generate new knowledge about gut-brain communication and how one of the major sensory nerves from the gut relays information about thirst and appetite sensations. The project addresses fundamental questions that rely on techniques only recently developed in our laboratory. We expect to demonstrate a major new sensory nerve pathway from the gut to the brain that plays a major role in appetite and thirst sensations. We will learn how gut to brain communication underlies the feeling of "fullness" when people consume food and drink.