Morphological and functional study on relationship between jaw osteoporosis and masticatory status

颌骨骨质疏松与咀嚼状态关系的形态和功能研究

• 批准号: 12307046
• 负责人: KOHNO Shoji
• 金额: $ 22.42万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12307046/
• 关键词: Postmenopausal Osteoporosis; Jaw boue; Ovariectomized monkey; Estrogen Deficiency; Mechanical stress; Mastication

1. Results of fundamental research on ovariectomized rat mandibleEstrogen deficiency caused osteoporotic changes of trabecular bone and thin alveolar bone proper in rat alveolar bone. Clinically, we must pay more attention to the state of periodontal disease and postmenopausal osteoporosis in elderly women.The loss of occlusion caused by the extrusion of the antagonistic tooth resulted in an increase of its alveolar bone height. However, the bone volume of the internal alveolar area was significantly lower. In addition, it was demonstrated that estrogen deficiency caused severe internal bone loss and weakened trabecular bone structures on the alveolar bone that lost mechanical loading with the antagonistic tooth, although it did not affect alveolar bone height.2. Results of fundamental research on ovariectomized monkey mandibleThe ovariectomized monkey mandibles showed porotic changes in the cortical and trabecular bone. Mandibular cortex data in particular correlated closely with lumbar porosis. The subject whose lumbar bone mineral density was lowest showed the lowest mandibular BMD and had porous mandibular and radial cortices. Therefore, information on the mandibular cortical bone seems useful in screening severe osteoporosis patients.3. Trials of measuring the BMD of human mandibleWe succeeded to measure the BMD of human mandible, however, the BMD values were easily changed by only small gap of measuring surface. Further improvement is necessary to resolve the problems.

1. 去卵巢大鼠下颌骨基础研究结果雌激素缺乏引起大鼠牙槽骨骨小梁骨和细牙槽骨的骨质疏松性改变。临床应重视老年妇女牙周病及绝经后骨质疏松的状况。拮抗牙挤压导致牙槽骨高度增高，牙合丧失。而内牙槽区骨体积明显降低。此外，研究表明，雌激素缺乏引起严重的内部骨质流失，削弱了拮抗牙失去机械负荷的牙槽骨的骨小梁结构，尽管它不影响牙槽骨高度。猴子去卵巢下颌骨的基础研究结果去卵巢下颌骨的皮质骨和骨小梁出现了多孔性改变。下颌骨皮质数据尤其与腰椎骨质疏松密切相关。腰椎骨密度最低的受试者下颌骨骨密度最低，下颌骨和桡骨皮质多孔。因此，关于下颌骨皮质骨的信息在筛查严重骨质疏松症患者时似乎是有用的。测量人类下颌骨骨密度的试验我们成功地测量了人类下颌骨骨密度，但由于测量表面只有很小的间隙，骨密度值很容易发生变化。要解决这些问题，需要进一步改进。

项目成果

田中みか子: "卵巣摘出サルを用いた下顎骨と腰椎の骨形態計測学的関連性に関する検討"日本骨形態計測学会雑誌. 10・1. 40 (2000)

Mikako Tanaka：“使用切除卵巢的猴子研究下颌骨和腰椎之间的骨形态测量关系”日本骨形态测量学会杂志 10/1。

Mikako Tanaka: "Region-specific bone mass changes in rat mandibular condyle following ovariectomy"J Dent Res. 79. 1907-1913 (2000)

Mikako Tanaka：“卵巢切除术后大鼠下颌髁突的区域特异性骨量变化”J Dent Res。

Mikako Tanaka: "Long-term changes on trabecular structure in aged rat alveolar bone following ovariectomy"Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 95(印刷中). (2003)

Mikako Tanaka：“卵巢切除术后老年大鼠牙槽骨小梁结构的长期变化”Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95（印刷中）。

Tanaka M, Toyooka E, Kohno S, Ozawa H, Ejiri S.: "Long-term changes on trabecular structurein aged rat alveolar bone following ovariectomy"Oral Surg Oral Med Oral Pathol Oral Radiol Endod. (in press).

Tanaka M、Toyooka E、Kohno S、Ozawa H、Ejiri S.：“卵巢切除术后老年大鼠牙槽骨小梁结构的长期变化”Oral Surg Oral Med Oral Pathol Oral Radiol Endod。

Mikako Tanaka: "Long-term changes on trabecular structure in aged rat alveolar bone following ovariectomy"Oral Med Oral Pathol Oral Radiol Endod. 95(印刷中). (2003)

Mikako Tanaka：“卵巢切除术后老年大鼠牙槽骨小梁结构的长期变化”Oral Med Oral Pathol Oral Radiol Endod 95（印刷中）。