Engineering micropatterned surfaces for cell mechanics and mechanobiology

用于细胞力学和机械生物学的微图案表面工程

• 批准号: DE220100205
• 负责人: Dr Navid Kashaninejad
• 金额: $ 31.14万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-04-04 至 2025-04-03
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE220100205
• 关键词: Engineering; micropatterned; surfaces; cell; mechanics

This project aims to engineer a highly versatile micropatterned surface that can be used to culture and study cells. This project expects to generate a unique microtechnology, as well as new knowledge in surface science and cell mechanics by elucidating the relationship between controlled surface wettability and cell behaviour. The expected outcomes of this project include a low-cost and highly engineered tissue culture tool that controls cellular functions, revolutionising practices in stem cell engineering. The platform technology has a great potential for commercialisation and enhancing Australian research capacity through international and interdisciplinary collaborations and will directly benefit the Australian biotech industry.

该项目旨在设计一种高度通用的微图案表面，可用于培养和研究细胞。该项目希望通过阐明受控表面润湿性与细胞行为之间的关系，产生独特的微技术，以及表面科学和细胞力学方面的新知识。该项目的预期成果包括一种低成本和高度工程化的组织培养工具，可以控制细胞功能，彻底改变干细胞工程的实践。该平台技术具有巨大的商业化潜力，通过国际和跨学科合作提高澳大利亚的研究能力，并将直接使澳大利亚的生物技术产业受益。