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Magnetic-field promotion in structures and functions of organized molecular membranes: Magnetic transportation of molecules and magnetofusion and magnetodivision of membranes

磁场促进有组织的分子膜的结构和功能：分子的磁传输以及膜的磁融合和磁分裂

基本信息

批准号：
12640555
负责人：
OZEKI Sutnio
金额：
$ 1.98万
依托单位：
Shinshu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

项目摘要

The membrane potential potential and resistance of a bimolecular membrane of lipids responded sensitively to steady magnetic fields. The largest changes occurred at around 0.15T, which corresponded to the smallest fixed charge density of the membrane. The response results in molecular orientation due to magnetic fields. When a lipid molecule tilts under a magnetic field, the occupied molecular area increases monotonically with a tilt angle and thus the charge density would also decrease monotonically with MF. On the other hand, with increasing the tilt angle, the hydrocarbon/water interface at the membrane surface should increase and destabilize the tilted structure: The critical tilt angle must exist. Then, one possible way to increase the charge density at higher MF than 0.15T would be to introduce membrane deformation in and out of a plain surface, which would lead to a reduction of the hydrocarbon/water interfacial energy and to relax the orientational defects ( among domains havin … More g diflerent orientation at a tilt angle ), respectively. Thus, the addition of magnetically anisotropic molecules to a membrane led to membrane potential regulation.Deformation in membranes of dipalmitoylphosphatidylcholine ( DPPC ) led to the fusion of its liposome and large changes in the membrane potential of its black membrane under high magnetic fields of up to 28 T. The magneto fusion of DPPC liposomes significantly depended on the particle size and aromatic compounds doped. Although a theory for the magnetic deformation of liposomes predicts magneto fusion and magnetodivision, only magneto fusion was experimentally observed There seem to be two discrete liposome sizes stabilized at 10T, 160 and 430 nm in radius. The changes in liposome size due to magneto fusion gives an estimation of the local curvature of the membrane. The membrane potential of black DPPC membranes markedly increased with high magnetic fields and doped molecules corresponding to magnetofusion. Undulation of a membrane due to high magnetic fields may relax any orientational defects in a black lipid membrane, leading to a ripple-like structure, which may cause the magnetoresponse in the membrane potential. Less

脂质双分子膜的膜电位和膜电阻对恒定磁场有敏感的响应。最大的变化发生在0.15T附近，这对应于膜的最小固定电荷密度。由于磁场，该响应导致分子取向。当脂质分子在磁场下倾斜时，占据的分子面积随着倾斜角单调增加，因此电荷密度也会随着MF单调减小。另一方面，随着倾斜角的增加，膜表面的碳氢化合物/水界面应该增加并使倾斜结构不稳定：临界倾斜角必须存在。然后，在高于0.15T的MF下增加电荷密度的一种可能的方法是在平坦表面内外引入膜变形，这将导致烃/水界面能的降低并松弛取向缺陷（在具有 ...更多信息 g在倾斜角处的不同取向）。在高达28 T的强磁场作用下，二棕榈酰磷脂酰胆碱（DPPC）膜的变形导致脂质体的融合和黑色膜的膜电位的大幅度变化。DPPC脂质体的磁融合与粒径及芳香族化合物的掺杂有关。尽管脂质体的磁变形理论预测了磁融合和磁分裂，但实验上仅观察到磁融合。似乎有两种离散的脂质体尺寸稳定在10 T，160和430 nm的半径。由于磁融合导致的脂质体大小的变化给出了膜的局部曲率的估计。黑色DPPC膜的膜电位显着增加与高磁场和相应的磁融合掺杂分子。由于高磁场引起的膜的波动可以松弛黑色脂质膜中的任何取向缺陷，导致波纹状结构，这可能导致膜电位中的磁响应。少