Establishment of non-invasive examination of swallowing patterns and changes in electrogastrogram during normal swwallowing.

建立正常吞咽过程中吞咽模式和胃电图变化的无创检查。

• 批准号: 12832065
• 负责人: HIGASHIJIMA Misako
• 金额: $ 2.3万
• 依托单位: Kawasaki University of Medical Welfare
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12832065/
• 关键词: swallowing; laryngeal movement; respiration; electrogastrogram; superior laryngeal nerve

This study was conducted to establish non-invasive examination of normal swallowing patterns, and to clarify gastric motility changes during normal swallowing. The results were as follows :(1) To examine normal patterns of swallowing, we investigated laryngeal movement, sound associated with swallowing and temperature of nasal cavity during voluntary swallowing. Furthermore, effects of cervical position and bolus volume on these parameters were investigated in normal adults. Voluntary swallowing was triggered by onset of a red lamp. Duration of laryngeal movement and deglutition apnea were significantly elongated when subjects swallowed 20cc water compared with 10cc water. In 10 degree dorsiflexion, latencies of laryngeal movement and deglutition apnea were significantly shortened and duration of laryngeal movement was elongated compared with those in 20 degree anteflexion. From these findings, it was suggested that healthy subjects retained at elevated position of larynx and palatum m … More olle to prevent misswallowing due to large volume of bolus. Water rapidly flowed into larynx in dorsiflexion. Thus, it was further suggested that subjects shortened onset of larynx and palatum molle movement and elongated laryngeal elevation when they swallowed in dorsiflexion.(2) To clarify changes in gastric motility associated with normal swallowing, elctrogastrogram (EGG) was recorded during voluntary swallowing and swallowing reflex elicited by injection of various solution. Amplitude of EGG was transiently increased by dilation of esophagus when subjects swallowed 20cc water. Injection of 0.05% citric acid, water and 0.9% NaCl into pharynx induced transient increase of amplitude of EGG. The amplitude of EGG increased in the order of citric acid > water > NaCl. The latency of swallowing reflex was also shortened in the order of citric acid > water > NaCl. From these findings, it was suggested that gastric motility is influenced by mechanical and chemical stimulation to pharyngeal and laryngeal region. Less

本研究旨在建立正常吞咽模式的无创检查，并阐明正常吞咽时胃动力的变化。结果如下：(1)为观察正常的吞咽模式，我们研究了自主吞咽时喉部运动、吞咽相关的声音和鼻腔温度。此外，在正常成人中研究了颈椎位置和丸量对这些参数的影响。自发吞咽是由红灯触发的。与10cc水相比，吞咽20cc水时喉部运动时间和吞咽呼吸暂停时间明显延长。与前屈20度组相比，后屈10度组喉运动潜伏期和吞咽呼吸暂停明显缩短，喉运动持续时间明显延长。由此可见，健康受试者应将喉部和腭部保持在较高的位置，以防止因大剂量服药而导致误咽。水在背屈时迅速流入喉部。因此，我们进一步认为，受试者在背屈吞咽时，喉部和腭部的运动开始时间缩短，喉部抬高时间延长。(2)为了明确正常吞咽时胃运动的变化，在自主吞咽和注射不同溶液引起的吞咽反射时记录胃电图（EGG）。当受试者吞下20cc水时，食管扩张使EGG振幅瞬间升高。咽部注射0.05%柠檬酸、水和0.9% NaCl，可引起卵泡蛋白振幅的短暂增加。EGG振幅按柠檬酸>水> NaCl的顺序增大。吞咽反射潜伏期按柠檬酸>水> NaCl的顺序依次缩短。由此可见，胃的运动受到对咽部的机械和化学刺激的影响。少

项目成果

東嶋美佐子, 古我知成: "嚥下量および頚部位置の違いに伴う嚥下時の喉頭運動・嚥下音・嚥下性無呼吸に及ぼす影響"作業療法. (印刷中). (2002)

Misako Higashishima、Tomonari Koga：“吞咽量和颈部位置的差异对吞咽过程中喉部运动、吞咽声音和吞咽呼吸暂停的影响”（出版中）。

Misako, Higashijima: "Trial of swallowing Training in a Group and its Effect"The Japanese Journal of Occupational Therapy. 36. 259-263 (2002)

东岛美佐子：“团体吞咽训练的试验及其效果”《日本职业治疗杂志》。

Misako, Higashijima: "Effect of cervical position and bolus volume on laryngeal movement, sound associated with swallowing and deglutition apnea"The Journal of Japanese Association of Occupational Therapists. (in press). (2002)

Misako, Higashijima：“颈椎位置和推注量对喉部运动、吞咽和吞咽呼吸暂停相关声音的影响”日本职业治疗师协会杂志。

Kobashi M., Koga T., Mizutani M., Matsuo R.: "Suppression of vagal motor activities evokes laryngeal afferent-mediated inhibition of gastric motility"Am J Physiol Regulatory Integrative Comp Physiol. 282. 818-827 (2001)

Kobashi M.、Koga T.、Mizutani M.、Matsuo R.：“迷走神经运动活动的抑制会引起喉部传入介导的胃运动抑制”Am J Physiol Regulatory Integrative Comp Physiol。

竹中 晋, 安部泰昌, 平岡崇, 椿原彰夫: "嚥下障害食と嚥下補助食品"日獨医報. 46(1). 54-58 (2001)

Susumu Takenaka、Yasumasa Abe、Takashi Hiraoka、Akio Tsubakihara：“吞咽困难食物和吞咽补充剂”Nichido Iho 46(1) (2001)。