遺伝子多型と骨格筋線維タイプの関係

遗传多态性与骨骼肌纤维类型的关系

• 批准号: 12878009
• 负责人: 田中 宏暁
• 金额: $ 1.15万
• 依托单位: Fukuoka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Exploratory Research
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12878009/
• 关键词: 長距離; 選手筋繊維タイプ; ACE genotype; AGT genotype; UCP2 genotype; UCP3 genotype; レニンアンギオテンシン; ACEgenotype; 筋バイオプシー; 筋繊維組成

骨格筋の筋線維タイプ、最大酸素摂取量、筋力などヒトのパフォーマンスを規定する因子は遺伝因子の影響を強く受けている。従って遺伝子多型や遺伝子変異とそれらの関係が注目される。今年はすでに持久能力が関連するとの先行研究があるACE遺伝子型について一流長距離選手と非鍛錬者の比較をした。その結果先行研究と異なりACE遺伝子型と持久能力に関係が認められなかった。骨格筋の筋線維タイプとの関連も例数を増やし検討し、ACEのII型にtype Iの割合が少ない傾向を示した。さらにAGT、UCP2、UCP3の多型との関連性を検討したが、いずれも明確な関連性は認められなかった。しかし鍛錬者と非鍛錬者に分類し骨格筋の筋線維タイプと遺伝子多型の関係をみると、鍛錬者はtype Iの割合が高く、UCP2-G-866A GG保有者が少なかった。Sedentary被験者においてACE-II保有者はACE-IDと-DD保有者よりType Iの割合が高く、Type IIxの割合が低かった。Athletesとsedentary被験者の間にACE-I/D遺伝子型の分布に有意差がなかったことから、athletesにおいてType Iの割合が高い機序には、環境的素因とACE-I/D遺伝子以外の他の遺伝的素因の関与が示唆された。

The factors affecting the determination of the tendon dimension, maximum acidity, and tendon strength are strongly influenced by the genetic factors. The relationship between genetic diversity and genetic diversity is important. This year's leading study on endurance is a comparison between first-class long-distance athletes and non-athletes. The results of the preliminary study are different from those of the ACE gene type and persistence ability. The number of cases related to the shape of the tendon increased, and the tendency of ACE type II to merge was shown. The relationship between AGT, UCP2 and UCP3 is discussed. UCP2-G-866A GG holder has a small number of connections between the two types. For Sedentary recipients, the ACE-II holders are higher than the ACE-ID and-DD holders, while the Type I holders are higher and the Type IIx holders are lower. The distribution of ACE-I/D gene types in athletes and sedentary subjects is intentionally different from that in athletes. The distribution of ACE-I/D gene types in athletes and sedentary subjects is intentionally different from that in athletes. The distribution of ACE-I/D gene types in athletes and sedentary subjects is intentionally different from that in athletes. The distribution of ACE-I/D gene types in athletes and sedentary subjects is intentionally different from that in athletes. The distribution of ACE-I/D gene types in athletes and sedentary subjects is intentionally different from that in athletes and sedentary subjects. The distribution of ACE-I/D gene types in athletes and sedentary subjects is intentionally different from that in athletes and sedentary subjects. The distribution of ACE-I/D gene types in athletes and sedentary subjects is intentionally different from that in athletes and sedentary subjects.