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Analysis of physiological and clinical significance of uterine contractions

子宫收缩的生理及临床意义分析

基本信息

批准号：
12670868
负责人：
TOGASHI Kaori
金额：
$ 1.98万
依托单位：
KYOTO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670868/
关键词：
Uterus MR Myometrium 筋層収縮 MR

项目摘要

The uterus has inherent contractility, and the inner myometrium is subjeci to subtle wave-like movements, which is called uterine peristalsis. It has been supposed to be involved into uterine functions including sperm transport or menstrual blood discharge, but is has not been well documented. Our purpose is to display this movement clearly on MR imaging that has excellent tissue contrast, and to elucidate the role of uterine peristalsis using cine MR imaging.During the first year of the research period, we mainly worked to develop the methods to display uterine peristalsis by means of MR imaging. Cine mode display of ultrafast MRl was capable of showing uterine peristalsis. Comparison of MR imaging with US has lead to the conclusion that MR imaging better demonstrated uterine peristalsis. Our results showed that uterine peristalsis and the junctional zone had close relationship. The second year of the research, we have added studies in women of perimenopausal period, studies to evaluate variations of uterine peristalsis during a day, relationship between dysmenorrhea and peristalsis. The direction and incidence of peristalsis varied according to menstrual cycle phases. The predominant direction was cervico-fundal during the periovulatory phase and fundocervical during the menstrual phase. Peristalsis subsided during the luteal phase. These directions were important in sperm transport, discharge of menstrual blood, and conservation of early pregnancies. Since disorders in peristalsis are hypothesized to be the causes of a variety of clinical symptoms such as dysmenorrhea, ultrafast MRl appears to be a powerful tool to elucidate the functions of the uterus.

子宫具有固有的收缩性，子宫内肌层会发生微妙的波浪状运动，称为子宫收缩。它被认为参与子宫功能，包括精子运输或经血排出，但尚未得到很好的证明。我们的目的是在具有良好组织对比度的MR成像上清楚地显示这种运动，并使用电影MR成像来阐明子宫脱垂的作用。在研究期间的第一年，我们主要致力于开发通过MR成像显示子宫脱垂的方法。超快MRI电影模式显示子宫肥大。比较磁共振成像与美国导致的结论，磁共振成像更好地显示子宫脱垂。结果表明，子宫脱垂与交界带关系密切。研究的第二年，我们增加了围绝经期妇女的研究，研究评估子宫脱垂在一天内的变化，痛经和脱垂之间的关系。子宫内膜异位症的方向和发病率根据月经周期的不同而不同。主要方向是子宫颈-子宫底在围排卵期和子宫底在月经期。蠕动在黄体期消退。这些指导在精子运输、经血排出和早期妊娠的保护方面很重要。由于子宫内膜异位症的疾病被假设为各种临床症状如痛经的原因，因此超快MRI似乎是阐明子宫功能的有力工具。