The effects of intrathecally administered anti-cholinesterase inhibitor on somato-Sympathetic reflex potentials

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We studied the analgesic and cardiovascular effect of intrathecally administered anti-cholinesterase inhibitor, neostigmine bromide (NB), using somato-symapathetic reflex as a parameter. The effects of intravenous administration of NB were also evaluated using same parameters.(Method)Somato-symapathetic reflex potentials (A and C reflex potentials ) which were derived from lumbar sympathetic ganglion of cats by electrical stimulation of femoral nerve were induced. NB was administered from intrathecally implanted PE-10 catheter or intravenous line in the forearm. Ten microgram, 50μg, 250μg and 2mg of NB was administered intrathecally and the change of somato-symapathetic reflex potentials was evaluated. Twenty microgram/kg, 100 μg/kg, 200 μg/kg of NB was administered intravenously and the change of somato-symapathetic reflex potentials was also evaluated.A reflex potential was reduced in dose dependent fashion by intrathecally administered NB but these changes were not significant. On the other hands, 250μg and 2mg of NB maximally reduced C reflex potential to 55.2% and 24.0% of control value respectively 20 minutes after the administration (p<0.01), and this reduction was reversed by 250 to 2mg of intrathecal administration of atropinc sulfatc to 89.4%, 68.6% of control value respectively. MAP and HR decreased in dose dependent fashion by NB to 57.6% , 65.2% of control value after the administration of 2 mg of NB and these cardiovascular change recovered by intrathecally administered atropine sulfate.Intravenously applied NB did not show significant effect on somato-symapathetic reflex potentials, MAP and HR.(Conclusion )(1) Intrathecally administered neostigmine bromide shows antinociceptive effect and this inhibition is partially mediated by colinergic mechanism.(2) Intravenous administration of NB did not show antinociceptive ettect.